MolNFT v1 · #24558 · protein
Acetyl-CoA carboxylase carboxyltransferase domain
1UYT: “Acetyl-CoA carboxylase carboxyltransferase domain”. X-ray diffraction, 20 pockets (best druggability 0.81). MolNFT v1 #24558 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1UYT
- Type
- protein
- Length
- 2,021 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acetyl-CoA carboxylase
- EC
- 6.4.1.2
- UniProt
- Q00955
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 39% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acetyl-CoA carboxylase (EC 6.4.1.2) | protein | 681 | 39% helix, 21% strand | Q00955 |
| B | Acetyl-CoA carboxylase (EC 6.4.1.2) | protein | 675 | 39% helix, 22% strand | Q00955 |
| C | Acetyl-CoA carboxylase (EC 6.4.1.2) | protein | 665 | 40% helix, 19% strand | Q00955 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 849 | 0.81 | 0.84 | 63 | empty |
| 2 | 481 | 0.76 | 0.85 | 36 | empty |
| 3 | 506 | 0.71 | 0.80 | 55 | empty |
| 4 | 364 | 0.71 | 0.83 | 42 | empty |
| 5 | 545 | 0.68 | 0.78 | 36 | empty |
Interfaces
2 interfaces between chains.
- B–C · 5769 Ų buried · 45 hydrogen bonds · protein-protein
- A–B · 1245 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00955
- Elsewhere: RCSB PDB 1UYT · PDBe 1UYT · UniProt Q00955
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