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Acetyl-CoA carboxylase carboxyltransferase domain

Analyse Acetyl-CoA carboxylase carboxyltransferase domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1UYT
Type
protein
Length
2,021 residues
Chains
3
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Acetyl-CoA carboxylase
EC
6.4.1.2
UniProt
Q00955
Pockets
20 · best druggability 0.81

Structure

x-ray diffraction · 3 distinct chains · 39% helix, 21% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AAcetyl-CoA carboxylase (EC 6.4.1.2)protein68139% helix, 21% strandQ00955
BAcetyl-CoA carboxylase (EC 6.4.1.2)protein67539% helix, 22% strandQ00955
CAcetyl-CoA carboxylase (EC 6.4.1.2)protein66540% helix, 19% strandQ00955

Pockets

20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
18490.810.8463empty
24810.760.8536empty
35060.710.8055empty
43640.710.8342empty
55450.680.7836empty

Interfaces

2 interfaces between chains.

  • B–C · 5769 Ų buried · 45 hydrogen bonds · protein-protein
  • A–B · 1245 Ų buried · 16 hydrogen bonds · protein-protein

Compared structures

  • 1UYT · Acetyl-CoA carboxylase carboxyltransferase domain · the same entry in another collection · chain A against A, TM-score 1.00
  • Q00955 · AlphaFold monomer V2.0 prediction for acetyl-CoA carboxylase (Q00955) · a predicted model of the same protein · chain C against A, TM-score 0.99

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