UniProt Q00955
Acetyl-CoA carboxylase (Q00955)
Acetyl-CoA carboxylase (UniProt Q00955), EC 6.3.4.14, 6.4.1.2: 51 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 42 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q00955
- Protein
- Acetyl-CoA carboxylase
- EC
- 6.3.4.14, 6.4.1.2
- Experimental structures
- 51
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 42 · 4 records with a druggable one
Structures
52 records of Q00955 in the MolNFT archive: 51 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1OD2 | Acetyl-CoA Carboxylase Carboxyltransferase Domain | x-ray diffraction | A, B | — | — |
| 1OD2 | Acetyl-CoA carboxylase carboxyltransferase domain | x-ray diffraction | A, B | — | — |
| 1OD4 | Acetyl-CoA Carboxylase Carboxyltransferase Domain | x-ray diffraction | A, B, C | — | — |
| 1OD4 | Acetyl-CoA carboxylase carboxyltransferase domain | x-ray diffraction | A, B, C | — | — |
| 1UYR | Acetyl-CoA Carboxylase Carboxyltransferase Domain in complex with inhibitor Diclofop | x-ray diffraction | A, B | — | — |
| 1UYR | Acetyl-CoA carboxylase carboxyltransferase domain in complex with inhibitor diclofop | x-ray diffraction | A, B | — | — |
| 1UYS | Acetyl-CoA carboxylase carboxyltransferase domain in complex with inhibitor haloxyfop | x-ray diffraction | A, B, C | — | — |
| 1UYS | Acetyl-CoA carboxylase carboxyltransferase domain in complex with inhibitor haloxyfop | x-ray diffraction | A, B, C | — | — |
| 1UYT | Acetyl-CoA carboxylase carboxyltransferase domain | x-ray diffraction | A, B, C | — | — |
| 1UYT | Acetyl-CoA carboxylase carboxyltransferase domain | x-ray diffraction | A, B, C | — | — |
| 1UYV | Acetyl-CoA carboxylase carboxyltransferase domain L1705I/V1967I mutant | x-ray diffraction | A, B, C | — | — |
| 1UYV | Acetyl-CoA carboxylase carboxyltransferase domain L1705I/ V1967I mutant | x-ray diffraction | A, B, C | — | — |
| 1W2X | Crystal structure of the carboxyltransferase domain of acetyl- coenzyme A carboxylase in complex… | x-ray diffraction | A, B, C | — | — |
| 1W2X | Crystal structure of the carboxyltransferase domain of acetyl-coenzyme a carboxylase in complex… | x-ray diffraction | A, B, C | — | — |
| 1W93 | Crystal Structure of Biotin Carboxylase Domain of Acetyl-Coenzyme A Carboxylase from Saccharomyces… | x-ray diffraction | A | — | — |
| 1W93 | Crystal structure of biotin carboxylase domain of acetyl- coenzyme a carboxylase from saccharomyces… | x-ray diffraction | A | — | — |
| 1W96 | Crystal Structure of Biotin Carboxylase Domain of Acetyl-coenzyme A Carboxylase from Saccharomyces… | x-ray diffraction | A, B, C | — | — |
| 1W96 | Crystal structure of biotin carboxylase domain of acetyl- coenzyme a carboxylase from saccharomyces… | x-ray diffraction | A, B, C | — | — |
| 3H0J | Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex… | x-ray diffraction | A, B, C | — | — |
| 3H0J | Crystal structure of the carboxyltransferase domain of acetyl-coenzyme a carboxylase in complex… | x-ray diffraction | A, B, C | — | — |
| 3H0Q | Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex… | x-ray diffraction | A, B, C | — | — |
| 3H0Q | Crystal structure of the carboxyltransferase domain of acetyl-coenzyme a carboxylase in complex… | x-ray diffraction | A, B, C | — | — |
| 3H0S | Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex… | x-ray diffraction | A, B, C | — | — |
| 3H0S | Crystal structure of the carboxyltransferase domain of acetyl-coenzyme a carboxylase in complex… | x-ray diffraction | A, B, C | — | — |
| 3K8X | Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex… | x-ray diffraction | A, B, C | — | — |
| 3K8X | Crystal structure of the carboxyltransferase domain of acetyl-coenzyme a carboxylase in complex… | x-ray diffraction | A, B, C | — | — |
| 3TV5 | Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in… | x-ray diffraction | A, B, C | — | — |
| 3TV5 | Crystal structure of the humanized carboxyltransferase domain of yeast acetyl-CoA caroxylase in… | x-ray diffraction | A, B, C | — | — |
| 3TVU | Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in… | x-ray diffraction | A, B, C | — | — |
| 3TVU | Crystal structure of the humanized carboxyltransferase domain of yeast acetyl-CoA caroxylase in… | x-ray diffraction | A, B, C | — | — |
| 3TVW | Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in… | x-ray diffraction | A, B, C | — | — |
| 3TVW | Crystal structure of the humanized carboxyltransferase domain of yeast acetyl-CoA caroxylase in… | x-ray diffraction | A, B, C | — | — |
| 3TZ3 | Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in… | x-ray diffraction | A, B, C | — | — |
| 3TZ3 | Crystal structure of the humanized carboxyltransferase domain of yeast acetyl-CoA caroxylase in… | x-ray diffraction | A, B, C | — | — |
| 4WYO | Crystal structure of human-yeast chimera acetyl CoA carboxylase ct domain bound to compound 1 | x-ray diffraction | B, C | — | — |
| 4WZ8 | Crystal structure of human-yeast chimera acetyl coA carboxylase CT domain bound to Compound 6 | x-ray diffraction | B, C | — | — |
| 4WZ8 | Crystal structure of human-yeast chimera acetyl CoA carboxylase ct domain bound to compound 6 | x-ray diffraction | B, C | — | — |
| 5CS0 | Crystal structure of domains AC1-AC2 of yeast acetyl-CoA carboxylase | x-ray diffraction | A, B | — | 1 (best 0.71) |
| 5CS0 | Crystal structure of domains AC1-AC2 of yeast acetyl-CoA carboxylase | x-ray diffraction | A, B | — | — |
| 5CS4 | Crystal structure of domains AC3-AC5 of yeast acetyl-CoA carboxylase | x-ray diffraction | A, B | — | — |
| 5CSA | Crystal structure of domains BT-BCCP-AC1-AC5 of yeast acetyl-CoA carboxylase | x-ray diffraction | A, B | — | 20 (best 0.80) |
| 5CSA | Crystal structure of domains bt-bccp-AC1-AC5 of yeast acetyl-CoA carboxylase | x-ray diffraction | A, B | — | — |
| 5CSK | Crystal structure of yeast acetyl-CoA carboxylase, unbiotinylated | x-ray diffraction | A, B | — | — |
| 5CSL | Crystal structure of the 500 kd yeast acetyl-CoA carboxylase holoenzyme dimer | x-ray diffraction | A, B | — | — |
| 5CTB | Humanized yeast acc carboxyltransferase domain bound to 6,7-dimethyl… | x-ray diffraction | A, B, C | — | — |
| 5CTC | Humanized yeast acc carboxyltransferase domain bound to tert-butyl 7… | x-ray diffraction | A, B, C | — | — |
| 5CTE | Humanized yeast acc carboxyltransferase domain bound to 2,2- dimethylpropyl… | x-ray diffraction | B, C | — | — |
| 5I6E | Crystal structure of the central domain of yeast acetyl-CoA carboxylase | x-ray diffraction | A | — | 9 (best 0.78) |
| 5I6E | Crystal structure of the central domain of yeast acetyl-CoA carboxylase | x-ray diffraction | A | — | — |
| 5TRC | Crystal structure of phosphorylated AC3-AC5 domains of yeast acetyl-CoA carboxylase | x-ray diffraction | A, B | CL | 12 (best 0.69) |
| 5TRC | Crystal structure of phosphorylated AC3-AC5 domains of yeast acetyl- CoA carboxylase | x-ray diffraction | A, B | CL | — |
| Q00955 | AlphaFold monomer V2.0 prediction for acetyl-CoA carboxylase (Q00955) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 2 records
Experiment against prediction
- 5CTC chain C against the predicted model Q00955: TM-score 0.99, RMSD 0.95 Å
- 3TV5 chain C against the predicted model Q00955: TM-score 0.99, RMSD 0.96 Å
- 3TV5 chain C against the predicted model Q00955: TM-score 0.99, RMSD 0.96 Å
- 3TVU chain C against the predicted model Q00955: TM-score 0.99, RMSD 0.96 Å
- 3TVU chain C against the predicted model Q00955: TM-score 0.99, RMSD 0.96 Å
- 3TZ3 chain C against the predicted model Q00955: TM-score 0.99, RMSD 0.97 Å
- 3TZ3 chain C against the predicted model Q00955: TM-score 0.99, RMSD 0.97 Å
- 5CTB chain C against the predicted model Q00955: TM-score 0.99, RMSD 0.97 Å
- 1UYT chain C against the predicted model Q00955: TM-score 0.99, RMSD 1.03 Å
- 1UYT chain C against the predicted model Q00955: TM-score 0.99, RMSD 1.03 Å
Elsewhere
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