MolNFT v1 · #24501 · protein

Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats

1UX6 · Thrombospondin-1: “Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats”. X-ray diffraction, 1 ligand (CA), 3 pockets (best druggability 0.58). MolNFT v1 #24501 on GenesisL1: 3D…

PDB: 1UX6
Type: protein
Length: 335 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Thrombospondin-1
UniProt: P07996
Ligands: CA
Pockets: 3 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Thrombospondin-1	protein	335	7% helix, 32% strand	P07996

Ligands and binding sites

CA · Calcium ion · metal · 16 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	299	0.58	0.77	29	empty
2	127	0.48	0.79	22	empty
3	50	0.42	0.84	15	empty

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1UX6 · Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the… · the same entry in another collection · chain A against A, TM-score 1.00
P07996 · AlphaFold monomer V2.0 prediction for thrombospondin-1 (P07996) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07996
Elsewhere: RCSB PDB 1UX6 · PDBe 1UX6 · UniProt P07996

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.