MolNFT v1 · #23667 · protein
Crystal structure of hpcna bound to residues 331-350 of the flap endonuclease-1 (FEN1)
1U7B · Proliferating cell nuclear antigen: “Crystal structure of hpcna bound to residues 331-350 of the flap endonuclease-1 (FEN1)”. X-ray diffraction, 1 pocket (best druggability 0.40). MolNFT v1 #23667 on GenesisL1: 3D structure, binding…
- PDB
- 1U7B
- Type
- protein
- Length
- 264 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proliferating cell nuclear antigen; Srqgstqgrlddffkvtgsl peptide of flap endonuclease-1
- UniProt
- P12004, P39748
- Pockets
- 1 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 19% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Proliferating cell nuclear antigen | protein | 251 | 19% helix, 47% strand | P12004 |
| B | Srqgstqgrlddffkvtgsl peptide of flap endonuclease-1 | protein | 13 | 23% helix, 15% strand | P39748 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.40 | 0.80 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 728 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 1U7B · Crystal structure of hPCNA bound to residues 331-350 of the flap endonuclease-1 (FEN1) · the same entry in another collection · chain A against A, TM-score 1.00
- P39748 · AlphaFold monomer V2.0 prediction for flap endonuclease 1 (P39748) · a predicted model of the same protein · chain B against A, TM-score 0.33
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12004
- Every structure of UniProt P39748
- Elsewhere: RCSB PDB 1U7B · PDBe 1U7B · UniProt P12004 · UniProt P39748
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