MolNFT v1 · #22277 · protein
Crystal structure of a complex between voltage-gated calcium channel BETA2A subunit and a peptide of the ALPHA1C subunit
1T0J · Voltage-gated calcium channel subunit BETA2A: “Crystal structure of a complex between voltage-gated calcium channel BETA2A subunit and a peptide of the…”. X-ray diffraction, 1 ligand (CL), 4 pockets (best druggability 0.37). MolNFT…
- PDB
- 1T0J
- Type
- protein
- Length
- 299 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Voltage-gated calcium channel subunit BETA2A; Voltage-dependent L-type calcium channel…
- UniProt
- Q8VGC3, Q13936
- Ligands
- CL
- Pockets
- 4 · best druggability 0.37
Structure
x-ray diffraction · 3 distinct chains · 43% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Voltage-gated calcium channel subunit BETA2A | protein | 96 | 31% helix, 28% strand | Q8VGC3 |
| B | Voltage-gated calcium channel subunit BETA2A | protein | 187 | 46% helix, 15% strand | Q8VGC3 |
| C | Voltage-dependent L-type calcium channel alpha-1C subunit | protein | 16 | 88% helix, 0% strand | Q13936 |
Ligands and binding sites
- CL · Chloride ion · ion · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 84 | 0.37 | 0.77 | 18 | empty |
| 2 | 57 | 0.36 | 0.79 | 19 | empty |
| 3 | 60 | 0.30 | 0.75 | 18 | empty |
| 4 | 51 | 0.27 | 0.73 | 15 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1100 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 794 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 1T0J · Crystal structure of a complex between voltage-gated calcium channel beta2a subunit and a… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8VGC3 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q13936 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain C against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8VGC3
- Every structure of UniProt Q13936
- Elsewhere: RCSB PDB 1T0J · PDBe 1T0J · UniProt Q8VGC3 · UniProt Q13936
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