MolNFT v1 · #22275 · protein
Crystal structure of the rattus norvegicus voltage gated calcium channel beta subunit isoform 2A
1T0H · Voltage-gated calcium channel subunit BETA2A: “Crystal structure of the rattus norvegicus voltage gated calcium channel beta subunit isoform 2A”. X-ray diffraction, 1 ligand (CL), 5 pockets (best druggability 0.37). MolNFT v1 #22275…
- PDB
- 1T0H
- Type
- protein
- Length
- 283 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Voltage-gated calcium channel subunit BETA2A
- UniProt
- Q8VGC3
- Ligands
- CL
- Pockets
- 5 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Voltage-gated calcium channel subunit BETA2A | protein | 96 | 31% helix, 26% strand | Q8VGC3 |
| B | Voltage-gated calcium channel subunit BETA2A | protein | 187 | 44% helix, 15% strand | Q8VGC3 |
Ligands and binding sites
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 91 | 0.37 | 0.76 | 18 | empty |
| 2 | 64 | 0.34 | 0.76 | 17 | empty |
| 3 | 65 | 0.32 | 0.75 | 15 | empty |
| 4 | 64 | 0.28 | 0.73 | 15 | empty |
| 5 | 59 | 0.28 | 0.73 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 846 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 modified (engineered).
Compared structures
- 1T0H · Crystal structure of the Rattus norvegicus voltage gated calcium channel beta subunit… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8VGC3 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8VGC3
- Elsewhere: RCSB PDB 1T0H · PDBe 1T0H · UniProt Q8VGC3
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