Research workbench
Crystal structure of the rattus norvegicus voltage gated calcium channel beta subunit isoform 2A
Analyse Crystal structure of the rattus norvegicus voltage gated calcium channel beta… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1T0H
- Type
- protein
- Length
- 283 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Voltage-gated calcium channel subunit BETA2A
- UniProt
- Q8VGC3
- Ligands
- CL
- Pockets
- 5 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Voltage-gated calcium channel subunit BETA2A | protein | 96 | 31% helix, 26% strand | Q8VGC3 |
| B | Voltage-gated calcium channel subunit BETA2A | protein | 187 | 44% helix, 15% strand | Q8VGC3 |
Ligands and binding sites
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 91 | 0.37 | 0.76 | 18 | empty |
| 2 | 64 | 0.34 | 0.76 | 17 | empty |
| 3 | 65 | 0.32 | 0.75 | 15 | empty |
| 4 | 64 | 0.28 | 0.73 | 15 | empty |
| 5 | 59 | 0.28 | 0.73 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 846 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 modified (engineered).
Compared structures
- 1T0H · Crystal structure of the Rattus norvegicus voltage gated calcium channel beta subunit… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8VGC3 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8VGC3
- Elsewhere: RCSB PDB 1T0H · PDBe 1T0H · UniProt Q8VGC3
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