MolNFT v1 · #22209 · protein

X-ray structure of the GLUR2 ligand-binding core (S1S2J) in complex with (S)-CPW399 at 1.85 a resolution.

1SYH · Glutamate receptor 2: “X-ray structure of the GLUR2 ligand-binding core (S1S2J) in complex with (S)-CPW399 at 1.85 a resolution.”. X-ray diffraction, 1 ligand (CPW), 2 pockets (best druggability 0.65). MolNFT v1 #22209 on GenesisL1…

PDB: 1SYH
Type: protein
Length: 259 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamate receptor 2
UniProt: P19491
Ligands: CPW
Pockets: 2 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutamate receptor 2	protein	259	38% helix, 21% strand	P19491

Ligands and binding sites

CPW · (S)-2-amino-3-(1,3,5,7-pentahydro-2,4-dioxo-cyclopenta[e]pyrimidin-1-yl) proionic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	123	0.65	0.88	25	CPW
2	164	0.47	0.77	28	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1SYH · X-ray structure of the GLUR2 ligand-binding core (S1S2J) in complex with (S)-CPW399 at… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19491
Elsewhere: RCSB PDB 1SYH · PDBe 1SYH · UniProt P19491

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.