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Ligand · CPW

CPW · (S)-2-amino-3-(1,3,5,7-pentahydro-2,4-dioxo-cyclopenta[e]pyrimidin-1-yl) proionic acid

CPW, (S)-2-amino-3-(1,3,5,7-pentahydro-2,4-dioxo-cyclopenta[e]pyrimidin-1-yl) proionic acid (C10 H13 N3 O4, 239.2 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues…

Component
CPW
Formula
C10 H13 N3 O4
Class
ligand
Structures
4
PDB entries
2

Binding sites

CPW in 4 structures; the first of them:

  • 1SYH · X-ray structure of the GLUR2 ligand-binding core (S1S2J) in complex with (S)-CPW399 at… · CPW A501 · binds GLU10, TYR13, TYR58, PRO86, LEU87, THR88, ARG93, LEU135 and 9 more
  • 1SYI · X-ray structure of the Y702F mutant of the GLUR2 ligand-binding core (S1S2J) in complex… · CPW A381 · binds GLU10, TYR58, PRO86, LEU87, THR88, ARG93, LEU135, GLY138 and 7 more
  • 1SYH · X-ray structure of the GLUR2 ligand-binding core (S1S2J) in complex with (S)-CPW399 at… · CPW A501 · binds GLU10, TYR13, TYR58, PRO86, LEU87, THR88, ARG93, LEU135 and 9 more
  • 1SYI · X-ray structure of the Y702F mutant of the GLUR2 ligand-binding core (S1S2J) in complex… · CPW A381 · binds GLU10, TYR58, PRO86, LEU87, THR88, ARG93, LEU135, GLY138 and 7 more

Residues it binds most

LEU 6, THR 6, TYR 6, GLU 6, SER 6, ARG 6, GLY 6, MET 6, PRO 6 (residue and the binding sites it lines).

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