MolNFT v1 · #22110 · protein
Structure of the K180P mutant of gi alpha subunit bound to ALF4 and GDP
1SVK · Guanine nucleotide-binding protein G(I), alpha-1 subunit: “Structure of the K180P mutant of gi alpha subunit bound to ALF4 and GDP”. X-ray diffraction, 3 ligands (ALF, GDP, MG), 3 pockets (best druggability 0.75). MolNFT v1 #22110…
- PDB
- 1SVK
- Type
- protein
- Length
- 313 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(I), alpha-1 subunit
- EC
- 3.6.1.46
- UniProt
- P10824
- Ligands
- ALF, GDP, MG
- Pockets
- 3 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(I), alpha-1 subunit (EC 3.6.1.46) | protein | 313 | 51% helix, 15% strand | P10824 |
Ligands and binding sites
- ALF · Tetrafluoroaluminate ion · ligand · chains A
- GDP · Guanosine-5'-diphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 164 | 0.75 | 0.92 | 31 | MG, ALF, GDP |
| 2 | 282 | 0.61 | 0.80 | 35 | empty |
| 3 | 67 | 0.29 | 0.73 | 11 | empty |
Compared structures
- 1SVK · Structure of the K180P mutant of Gi alpha subunit bound to AlF4 and GDP · the same entry in another collection · chain A against A, TM-score 1.00
- P10824 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10824
- Elsewhere: RCSB PDB 1SVK · PDBe 1SVK · UniProt P10824
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