MolNFT v1 · #21837 · protein

Crystal structure of the S1 domain of RNase E from E. COLI (native)

1SMX · Ribonuclease E: “Crystal structure of the S1 domain of RNase E from E. COLI (native)”. X-ray diffraction, 1 pocket (best druggability 0.48). MolNFT v1 #21837 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1SMX
Type: protein
Length: 168 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribonuclease E
EC: 3.1.4.-
UniProt: P21513
Pockets: 1 · best druggability 0.48

Structure

x-ray diffraction · 2 distinct chains · 15% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribonuclease E (EC 3.1.4.-)	protein	87	14% helix, 36% strand	P21513
B	Ribonuclease E (EC 3.1.4.-)	protein	81	16% helix, 38% strand	P21513

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	180	0.48	0.76	23	empty

Interfaces

1 interface between chains.

A–B · 668 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

1SMX · Crystal structure of the S1 domain of RNase E from E. coli (native) · the same entry in another collection · chain A against A, TM-score 1.00
P21513 · AlphaFold monomer V2.0 prediction for ribonuclease E (P21513) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21513
Elsewhere: RCSB PDB 1SMX · PDBe 1SMX · UniProt P21513

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