MolNFT v1 · #2169 · protein
Human methionine aminopeptidase 2 complexed with angiogenesis inhibitor fumagillin
1BOA: “Human methionine aminopeptidase 2 complexed with angiogenesis inhibitor fumagillin”. X-ray diffraction, 2 ligands (FUG, CO), 4 pockets (best druggability 0.69). MolNFT v1 #2169 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1BOA
- Type
- protein
- Length
- 354 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methionine aminopeptidase
- EC
- 3.4.11.18
- UniProt
- P50579
- Ligands
- FUG, CO
- Pockets
- 4 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methionine aminopeptidase (EC 3.4.11.18) | protein | 354 | 31% helix, 27% strand | P50579 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 280 | 0.69 | 0.84 | 39 | FUG |
| 2 | 60 | 0.50 | 0.85 | 16 | empty |
| 3 | 56 | 0.30 | 0.75 | 21 | empty |
| 4 | 52 | 0.26 | 0.73 | 14 | empty |
Modifications
Observed in the structure: 1 covalent, 1 disulfide (covalent ligand, disulfide).
Compared structures
- 1BOA · Human methionine aminopeptidase 2 complexed with angiogenesis inhibitor fumagillin · the same entry in another collection · chain A against A, TM-score 1.00
- P50579 · AlphaFold monomer V2.0 prediction for methionine aminopeptidase 2 (P50579) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P50579
- Elsewhere: RCSB PDB 1BOA · PDBe 1BOA · UniProt P50579
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.