MolNFT v1 · #2049 · protein

Complex of human H-RAS with human sos-1

1BKD: “Complex of human H-RAS with human sos-1”. X-ray diffraction, 11 pockets (best druggability 0.73). MolNFT v1 #2049 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1BKD
Type: protein
Length: 605 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: H-RAS; Son of sevenless-1
UniProt: P01112, Q07889
Pockets: 11 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
R	H-RAS	protein	166	36% helix, 25% strand	P01112
S	Son of sevenless-1	protein	439	57% helix, 4% strand	Q07889

Pockets

11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	363	0.73	0.84	47	empty
2	331	0.68	0.82	55	empty
3	243	0.47	0.73	38	empty
4	104	0.39	0.76	18	empty
5	102	0.38	0.75	19	empty

Interfaces

1 interface between chains.

R–S · 1719 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

1BKD · Complex of human H-RAS with human sos-1 · the same entry in another collection · chain R against R, TM-score 1.00
Q07889 · AlphaFold monomer V2.0 prediction for son of sevenless homolog 1 (Q07889) · a predicted model of the same protein · chain S against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01112
Every structure of UniProt Q07889
Elsewhere: RCSB PDB 1BKD · PDBe 1BKD · UniProt P01112 · UniProt Q07889

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