MolNFT v1 · #19791 · protein
Complex of replication protein a subunits RPA14 and RPA32
1QUQ · Protein (replication protein a 32 kd subunit): “Complex of replication protein a subunits RPA14 and RPA32”. X-ray diffraction, 4 pockets (best druggability 0.33). MolNFT v1 #19791 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1QUQ
- Type
- protein
- Length
- 469 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (replication protein a 32 kd subunit); Protein (replication protein a 14 kd…
- UniProt
- P15927, P35244
- Pockets
- 4 · best druggability 0.33
Structure
x-ray diffraction · 4 distinct chains · 17% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (replication protein a 32 kd subunit) | protein | 121 | 14% helix, 45% strand | P15927 |
| B | Protein (replication protein a 14 kd subunit) | protein | 114 | 19% helix, 35% strand | P35244 |
| C | Protein (replication protein a 32 kd subunit) | protein | 119 | 15% helix, 46% strand | P15927 |
| D | Protein (replication protein a 14 kd subunit) | protein | 115 | 19% helix, 36% strand | P35244 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.33 | 0.77 | 18 | empty |
| 2 | 62 | 0.31 | 0.75 | 12 | empty |
| 3 | 55 | 0.31 | 0.76 | 15 | empty |
| 4 | 50 | 0.25 | 0.73 | 14 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1327 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 1214 Ų buried · 13 hydrogen bonds · protein-protein
- B–D · 278 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 237 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 211 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1QUQ · Complex of replication protein a subunits RPA14 and RPA32 · the same entry in another collection · chain D against D, TM-score 1.00
- P35244 · AlphaFold monomer V2.0 prediction for replication protein a 14 kda subunit (P35244) · a predicted model of the same protein · chain D against A, TM-score 0.98
- P15927 · AlphaFold monomer V2.0 prediction for replication protein a 32 kda subunit (P15927) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15927
- Every structure of UniProt P35244
- Elsewhere: RCSB PDB 1QUQ · PDBe 1QUQ · UniProt P15927 · UniProt P35244
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