MolNFT v1 · #19565 · protein
Molecular architecture of the rotary motor in ATP synthase from yeast mitochondria
1QO1 · ATP synthase alpha chain: “Molecular architecture of the rotary motor in ATP synthase from yeast mitochondria”. X-ray diffraction, 20 pockets (best druggability 0.60). MolNFT v1 #19565 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1QO1
- Type
- protein
- Length
- 3,912 residues
- Chains
- 18
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP synthase alpha chain; ATP synthase beta chain; ATP synthase gamma chain; ATP synthase…
- EC
- 3.6.1.34
- UniProt
- P19483, P00829, P05631, P00832, P00844
- Pockets
- 20 · best druggability 0.60
Structure
x-ray diffraction · 7 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | ATP synthase alpha chain (EC 3.6.1.34) | protein | 487 | 0% helix, 0% strand | P19483 |
| C | ATP synthase alpha chain (EC 3.6.1.34) | protein | 492 | 0% helix, 0% strand | P19483 |
| D | ATP synthase beta chain (EC 3.6.1.34) | protein | 467 | 0% helix, 0% strand | P00829 |
| E, F | ATP synthase beta chain (EC 3.6.1.34) | protein | 466 | 0% helix, 0% strand | P00829 |
| G | ATP synthase gamma chain (EC 3.6.1.34) | protein | 122 | 0% helix, 0% strand | P05631 |
| J | ATP synthase delta chain (EC 3.6.1.34) | protein | 135 | 0% helix, 0% strand | P00832 |
| K, L, M, N, O, P, Q, R, S, T | ATP synthase protein 9 (EC 3.6.1.34) | protein | 79 | 0% helix, 0% strand | P00844 |
Pockets
20 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 407 | 0.60 | 0.74 | 90 | empty |
| 2 | 267 | 0.52 | 0.73 | 66 | empty |
| 3 | 233 | 0.52 | 0.74 | 45 | empty |
| 4 | 217 | 0.50 | 0.73 | 48 | empty |
| 5 | 205 | 0.47 | 0.73 | 48 | empty |
Interfaces
24 interfaces between chains.
- C–D · 463 Ų buried · 0 hydrogen bonds · protein-protein
- O–P · 431 Ų buried · 0 hydrogen bonds · protein-protein
- K–T · 410 Ų buried · 0 hydrogen bonds · protein-protein
- R–S · 410 Ų buried · 0 hydrogen bonds · protein-protein
- P–Q · 408 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1QO1 · Molecular Architecture of the Rotary Motor in ATP Synthase from Yeast Mitochondria · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19483
- Every structure of UniProt P00829
- Every structure of UniProt P05631
- Every structure of UniProt P00832
- Every structure of UniProt P00844
- Elsewhere: RCSB PDB 1QO1 · PDBe 1QO1 · UniProt P19483 · UniProt P00829 · UniProt P05631 · UniProt P00832 · UniProt P00844
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