MolNFT v1 · #19311 · protein
Structure of importin beta bound to the ibb domain of importin alpha (II crystal form, grown at low pH)
1QGR · Protein (importin beta subunit): “Structure of importin beta bound to the ibb domain of importin alpha (II crystal form, grown at low pH)”. X-ray diffraction, 9 pockets (best druggability 0.67). MolNFT v1 #19311 on GenesisL1: 3D…
- PDB
- 1QGR
- Type
- protein
- Length
- 895 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (importin beta subunit); Protein (importin alpha-2 subunit)
- UniProt
- Q14974, P52292
- Pockets
- 9 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (importin beta subunit) | protein | 871 | 77% helix, 0% strand | Q14974 |
| B | Protein (importin alpha-2 subunit) | protein | 24 | 79% helix, 0% strand | P52292 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 539 | 0.67 | 0.78 | 60 | empty |
| 2 | 83 | 0.65 | 0.91 | 21 | empty |
| 3 | 257 | 0.62 | 0.81 | 35 | empty |
| 4 | 254 | 0.52 | 0.75 | 32 | empty |
| 5 | 139 | 0.45 | 0.76 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1139 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 1QGR · Structure of importin beta bound to the ibb domain of importin alpha (II crystal form… · the same entry in another collection · chain A against A, TM-score 1.00
- Q14974 · AlphaFold monomer V2.0 prediction for importin subunit beta-1 (Q14974) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P52292 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52292) · a predicted model of the same protein · chain B against A, TM-score 0.61
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14974
- Every structure of UniProt P52292
- Elsewhere: RCSB PDB 1QGR · PDBe 1QGR · UniProt Q14974 · UniProt P52292
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