MolNFT v1 · #19304 · protein
Structure of importin beta bound to the ibb domain of importin alpha
1QGK · Protein (importin beta subunit): “Structure of importin beta bound to the ibb domain of importin alpha”. X-ray diffraction, 12 pockets (best druggability 0.73). MolNFT v1 #19304 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1QGK
- Type
- protein
- Length
- 920 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (importin beta subunit); Protein (importin alpha-2 subunit)
- UniProt
- Q14974, P52292
- Pockets
- 12 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (importin beta subunit) | protein | 876 | 76% helix, 0% strand | Q14974 |
| B | Protein (importin alpha-2 subunit) | protein | 44 | 70% helix, 0% strand | P52292 |
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 120 | 0.73 | 0.94 | 29 | empty |
| 2 | 165 | 0.69 | 0.88 | 29 | empty |
| 3 | 355 | 0.64 | 0.79 | 38 | empty |
| 4 | 282 | 0.60 | 0.79 | 30 | empty |
| 5 | 211 | 0.49 | 0.75 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 2002 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 1QGK · Structure of importin beta bound to the ibb domain of importin alpha · the same entry in another collection · chain A against A, TM-score 1.00
- Q14974 · AlphaFold monomer V2.0 prediction for importin subunit beta-1 (Q14974) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P52292 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52292) · a predicted model of the same protein · chain B against A, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14974
- Every structure of UniProt P52292
- Elsewhere: RCSB PDB 1QGK · PDBe 1QGK · UniProt Q14974 · UniProt P52292
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