MolNFT v1 · #191250 · protein
Human glycogenin-1 and glycogen synthase-1 complex in the apo mobile state
8CVY · Glycogen [starch] synthase, muscle: “Human glycogenin-1 and glycogen synthase-1 complex in the apo mobile state”. Electron microscopy, 20 pockets (best druggability 0.71). MolNFT v1 #191250 on GenesisL1: 3D structure, binding sites…
- PDB
- 8CVY
- Type
- protein
- Length
- 2,226 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycogen [starch] synthase, muscle; Glycogenin-1
- EC
- 2.4.1.11, 2.4.1.186
- UniProt
- P13807, P46976
- Pockets
- 20 · best druggability 0.71
Structure
electron microscopy · 4 distinct chains · 49% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D | Glycogen [starch] synthase, muscle (EC 2.4.1.11) | protein | 605 | 49% helix, 13% strand | P13807 |
| E | Glycogenin-1 (EC 2.4.1.186) | protein | 33 | 58% helix, 0% strand | P46976 |
| G, H | Glycogenin-1 (EC 2.4.1.186) | protein | 34 | 59% helix, 0% strand | P46976 |
| B | Glycogen [starch] synthase, muscle (EC 2.4.1.11) | protein | 310 | 49% helix, 11% strand | P13807 |
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 435 | 0.71 | 0.82 | 50 | empty |
| 2 | 349 | 0.64 | 0.79 | 31 | empty |
| 3 | 445 | 0.63 | 0.76 | 47 | empty |
| 4 | 446 | 0.62 | 0.76 | 50 | empty |
| 5 | 361 | 0.61 | 0.77 | 43 | empty |
Interfaces
9 interfaces between chains.
- A–D · 1518 Ų buried · 5 hydrogen bonds · protein-protein
- C–B · 1486 Ų buried · 5 hydrogen bonds · protein-protein
- C–G · 1236 Ų buried · 13 hydrogen bonds · protein-protein
- A–E · 1232 Ų buried · 17 hydrogen bonds · protein-protein
- D–H · 1223 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 8CVY · Human glycogenin-1 and glycogen synthase-1 complex in the apo mobile state · the same entry in another collection · chain B against B, TM-score 1.00
- P13807 · AlphaFold monomer V2.0 prediction for glycogen [starch] synthase, muscle (P13807) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P46976 · AlphaFold monomer V2.0 prediction for glycogenin-1 (P46976) · a predicted model of the same protein · chain E against A, TM-score 0.75
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13807
- Every structure of UniProt P46976
- Elsewhere: RCSB PDB 8CVY · PDBe 8CVY · UniProt P13807 · UniProt P46976
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