MolNFT v1 · #190970 · protein
Cryo-EM structure of the human gs-gn complex in the inhibited state
7ZBN · Glycogen [starch] synthase, muscle: “Cryo-EM structure of the human gs-gn complex in the inhibited state”. Electron microscopy, 20 pockets (best druggability 0.70). MolNFT v1 #190970 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7ZBN
- Type
- protein
- Length
- 2,608 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycogen [starch] synthase, muscle; Isoform gn-1 of glycogenin-1
- EC
- 2.4.1.11, 2.4.1.186
- UniProt
- P13807, P46976
- Pockets
- 20 · best druggability 0.70
Structure
electron microscopy · 3 distinct chains · 49% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Glycogen [starch] synthase, muscle (EC 2.4.1.11) | protein | 617 | 49% helix, 14% strand | P13807 |
| B, D | Glycogen [starch] synthase, muscle (EC 2.4.1.11) | protein | 621 | 49% helix, 14% strand | P13807 |
| E, F, G, H | Isoform gn-1 of glycogenin-1 (EC 2.4.1.186) | protein | 33 | 58% helix, 0% strand | P46976 |
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 706 | 0.70 | 0.77 | 67 | empty |
| 2 | 681 | 0.70 | 0.77 | 66 | empty |
| 3 | 692 | 0.70 | 0.77 | 66 | empty |
| 4 | 706 | 0.69 | 0.77 | 70 | empty |
| 5 | 561 | 0.65 | 0.76 | 63 | empty |
Interfaces
10 interfaces between chains.
- B–D · 1452 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 1447 Ų buried · 5 hydrogen bonds · protein-protein
- D–H · 1304 Ų buried · 14 hydrogen bonds · protein-protein
- B–F · 1302 Ų buried · 14 hydrogen bonds · protein-protein
- A–E · 1294 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 7ZBN · Cryo-EM structure of the human GS-GN complex in the inhibited state · the same entry in another collection · chain H against H, TM-score 1.00
- P13807 · AlphaFold monomer V2.0 prediction for glycogen [starch] synthase, muscle (P13807) · a predicted model of the same protein · chain D against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13807
- Every structure of UniProt P46976
- Elsewhere: RCSB PDB 7ZBN · PDBe 7ZBN · UniProt P13807 · UniProt P46976
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