MolNFT v1 · #190788 · protein
Structure of the P22PHOX A200G mutant in complex with P47PHOX peptide
7YXW · Cytochrome B-245 light chain: “Structure of the P22PHOX A200G mutant in complex with P47PHOX peptide”. X-ray diffraction, 1 pocket (best druggability 0.47). MolNFT v1 #190788 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7YXW
- Type
- protein
- Length
- 139 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytochrome B-245 light chain; Neutrophil cytosol factor 1
- UniProt
- P13498, P14598
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | Cytochrome B-245 light chain | protein | 11 | 0% helix, 0% strand | P13498 |
| A | Neutrophil cytosol factor 1 | protein | 128 | 5% helix, 44% strand | P14598 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 129 | 0.47 | 0.78 | 20 | empty |
Interfaces
1 interface between chains.
- D–A · 729 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 7YXW · Structure of the p22phox A200G mutant in complex with p47phox peptide · the same entry in another collection · chain D against D, TM-score 1.00
- P14598 · AlphaFold monomer V2.0 prediction for neutrophil cytosol factor 1 (P14598) · a predicted model of the same protein · chain A against A, TM-score 0.87
- P13498 · AlphaFold monomer V2.0 prediction for cytochrome B-245 light chain (P13498) · a predicted model of the same protein · chain D against A, TM-score 0.42
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13498
- Every structure of UniProt P14598
- Elsewhere: RCSB PDB 7YXW · PDBe 7YXW · UniProt P13498 · UniProt P14598
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