UniProt P14598
neutrophil cytosol factor 1 (P14598)
neutrophil cytosol factor 1 (UniProt P14598): 21 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 46 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P14598
- Protein
- neutrophil cytosol factor 1
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 46 · 5 records with a druggable one
Structures
22 records of P14598 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GD5 | Solution structure of the px domain from human P47PHOX NADPH oxidase | solution nmr | A | — | 3 (best 0.39) |
| 1GD5 | Solution structure of the px domain from human P47PHOX NADPH oxidase | solution nmr | A | — | 3 (best 0.39) |
| 1K4U | Solution structure of the C-terminal SH3 domain of p67phox complexed with the C-terminal tail… | solution nmr | P | — | — |
| 1K4U | Solution structure of the C-terminal SH3 domain of P67PHOX complexed with the C-terminal tail… | solution nmr | P | — | — |
| 1KQ6 | p47phox PX domain | x-ray diffraction | A | SO4 | 2 (best 0.41) |
| 1KQ6 | P47PHOX px domain | x-ray diffraction | A | SO4 | 2 (best 0.41) |
| 1NG2 | Structure of autoinhibited p47phox | x-ray diffraction | A | — | 3 (best 0.45) |
| 1NG2 | Structure of autoinhibited P47PHOX | x-ray diffraction | A | — | 3 (best 0.45) |
| 1O7K | human p47 PX domain complex with sulphates | x-ray diffraction | A, B, C | SO4 | 4 (best 0.79) |
| 1O7K | Human P47 px domain complex with sulphates | x-ray diffraction | A, B, C | SO4 | 4 (best 0.79) |
| 1OV3 | Structure of the p22phox-p47phox complex | x-ray diffraction | A, B | — | 2 (best 0.44) |
| 1OV3 | Structure of the P22PHOX-P47PHOX complex | x-ray diffraction | A, B | — | 2 (best 0.44) |
| 1UEC | Crystal structure of autoinhibited form of tandem SH3 domain of p47phox | x-ray diffraction | A | — | 3 (best 0.52) |
| 1UEC | Crystal structure of autoinhibited form of tandem SH3 domain of P47PHOX | x-ray diffraction | A | — | 3 (best 0.52) |
| 1W70 | SH3 domain of p40phox complexed with C-terminal polyProline region of p47phox | x-ray diffraction | C, D | — | 1 (best 0.33) |
| 1W70 | SH3 domain of P40PHOX complexed with C-terminal polyproline region of P47PHOX | x-ray diffraction | C, D | ACE | 1 (best 0.33) |
| 1WLP | Solution Structure Of The P22Phox-P47Phox Complex | solution nmr | B | — | 1 (best 0.42) |
| 1WLP | Solution structure of the P22PHOX-P47PHOX complex | solution nmr | B | — | 1 (best 0.42) |
| 7YXW | Structure of the p22phox A200G mutant in complex with p47phox peptide | x-ray diffraction | A | — | 1 (best 0.47) |
| 7YXW | Structure of the P22PHOX A200G mutant in complex with P47PHOX peptide | x-ray diffraction | A | — | 1 (best 0.47) |
| 8WEJ | Structure of human phagocyte NADPH oxidase in the activated state | electron microscopy | C | — | 1 (best 0.45) |
| P14598 | AlphaFold monomer V2.0 prediction for neutrophil cytosol factor 1 (P14598) | predicted | A | — | 5 (best 0.72) |
Ligands
Experiment against prediction
- 1O7K chain B against the predicted model P14598: TM-score 0.95, RMSD 1.44 Å
- 1O7K chain B against the predicted model P14598: TM-score 0.95, RMSD 1.44 Å
- 1O7K chain A against the predicted model P14598: TM-score 0.93, RMSD 1.42 Å
- 1O7K chain A against the predicted model P14598: TM-score 0.93, RMSD 1.42 Å
- 1KQ6 chain A against the predicted model P14598: TM-score 0.92, RMSD 1.79 Å
- 1KQ6 chain A against the predicted model P14598: TM-score 0.92, RMSD 1.79 Å
- 7YXW chain A against the predicted model P14598: TM-score 0.87, RMSD 1.69 Å
- 7YXW chain A against the predicted model P14598: TM-score 0.87, RMSD 1.69 Å
- 1WLP chain B against the predicted model P14598: TM-score 0.82, RMSD 2.42 Å
- 1WLP chain B against the predicted model P14598: TM-score 0.82, RMSD 2.42 Å
Elsewhere
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