MolNFT v1 · #7661 · protein

Solution structure of the px domain from human P47PHOX NADPH oxidase

1GD5 · Neutrophil cytosol factor 1: “Solution structure of the px domain from human P47PHOX NADPH oxidase”. Solution nmr, 3 pockets (best druggability 0.39). MolNFT v1 #7661 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1GD5
Type: protein
Length: 130 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neutrophil cytosol factor 1
UniProt: P14598
Pockets: 3 · best druggability 0.39

Structure

solution nmr · 1 distinct chain · 33% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Neutrophil cytosol factor 1	protein	130	33% helix, 19% strand	P14598

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	65	0.39	0.79	13	empty
2	50	0.37	0.80	12	empty
3	90	0.35	0.74	13	empty

Compared structures

1GD5 · Solution structure of the px domain from human P47PHOX NADPH oxidase · the same entry in another collection · chain A against A, TM-score 1.00
P14598 · AlphaFold monomer V2.0 prediction for neutrophil cytosol factor 1 (P14598) · a predicted model of the same protein · chain A against A, TM-score 0.71

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14598
Elsewhere: RCSB PDB 1GD5 · PDBe 1GD5 · UniProt P14598

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