MolNFT v1 · #190717 · protein

Cryo-EM structure of the NA+,K+-ATPase in the E2.2K+ state

7Y45: “Cryo-EM structure of the NA+,K+-ATPase in the E2.2K+ state”. Electron microscopy, 7 ligands (PCW, CLR, NAG). MolNFT v1 #190717 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7Y45
Type: protein
Length: 2,654 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q4H132, C4IX13, Q70Q12
Ligands: PCW, CLR, NAG, MAN, BMA, FUC, K

Structure

electron microscopy · 3 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C, A	—	protein	993	—	Q4H132
D, B	—	protein	294	—	C4IX13
E, G	—	protein	40	—	Q70Q12

Ligands and binding sites

PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · ligand · 26 copies · chains C, D, A, B, E, G
CLR · Cholesterol · ligand · 8 copies · chains C, E, D, A, G, B
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 18 copies · chains D, B
MAN · alpha-D-mannopyranose · sugar · 10 copies · chains D, B
BMA · beta-D-mannopyranose · sugar · 6 copies
FUC · alpha-L-fucopyranose · sugar · 4 copies · chains D, B
K · Potassium ion · metal · 6 copies · chains C, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7Y45 · Cryo-EM structure of the Na+,K+-ATPase in the E2.2K+ state · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4H132
Every structure of UniProt C4IX13
Every structure of UniProt Q70Q12
Elsewhere: RCSB PDB 7Y45 · PDBe 7Y45 · UniProt Q4H132 · UniProt C4IX13 · UniProt Q70Q12

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