MolNFT v1 · #190187 · protein
X-ray structure of thermostabilized drosophila dopamine transporter with GABA TRANSPORTER1-like substitutions in the binding site, in complex with SKF89976A
7WLW: “X-ray structure of thermostabilized drosophila dopamine transporter with GABA TRANSPORTER1-like substitutions…”. X-ray diffraction, 5 ligands (1WR, Y01, CLR). MolNFT v1 #190187 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 7WLW
- Type
- protein
- Length
- 969 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q7K4Y6
- Ligands
- 1WR, Y01, CLR, NA, CL
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 536 | — | Q7K4Y6 |
| L | — | protein | 214 | — | — |
| H | — | protein | 219 | — | — |
Ligands and binding sites
- 1WR · (3S)-1-(4,4-diphenylbut-3-enyl)piperidine-3-carboxylic acid · ligand · 2 copies · chains A
- Y01 · Cholesterol hemisuccinate · ligand · chains A
- CLR · Cholesterol · ligand · chains A
- NA · Sodium ion · metal · 2 copies · chains A
- CL · Chloride ion · ion · chains A
- DMU · Decyl-beta-D-maltopyranoside · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7WLW · X-ray structure of thermostabilized Drosophila dopamine transporter with GABA… · the same entry in another collection · chain A against A, TM-score 1.00
- Q7K4Y6 · AlphaFold monomer V2.0 prediction for sodium-dependent dopamine transporter (Q7K4Y6) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7K4Y6
- Elsewhere: RCSB PDB 7WLW · PDBe 7WLW · UniProt Q7K4Y6
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