MolNFT v1 · #190180 · protein
Cryoem structure of human low-voltage activated T-type calcium channel CAV3.3 in complex with mibefradil (mib)
7WLJ: “Cryoem structure of human low-voltage activated T-type calcium channel CAV3.3 in complex with mibefradil (mib)”. Electron microscopy, 5 ligands (Y01, 3PE, MWV). MolNFT v1 #190180 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 7WLJ
- Type
- protein
- Length
- 1,135 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9P0X4
- Ligands
- Y01, 3PE, MWV, NAG, CA
Structure
electron microscopy · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1135 | — | Q9P0X4 |
Ligands and binding sites
- Y01 · Cholesterol hemisuccinate · ligand · 6 copies · chains A
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · ligand · 5 copies · chains A
- MWV · (1S,2S)-2-(2-{[3-(1H-benzimidazol-2-yl)propyl](methyl) amino}ethyl)-6-fluoro-1-(propan-2-yl)-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7WLJ · CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9P0X4 · AlphaFold monomer V2.0 prediction for voltage-dependent T-type calcium channel subunit… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9P0X4
- Elsewhere: RCSB PDB 7WLJ · PDBe 7WLJ · UniProt Q9P0X4
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