MolNFT v1 · #190144 · protein

Architecture of the human nalcn channelosome

7WJI · Protein unc-80 homolog: “Architecture of the human nalcn channelosome”. Electron microscopy, 20 pockets (best druggability 0.89). MolNFT v1 #190144 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7WJI
Type: protein
Length: 5,128 residues
Chains: 5
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein unc-80 homolog; Protein unc-79 homolog; Calmodulin-1; Sodium leak channel…
UniProt: Q8N2C7, Q9P2D8, P0DP23, Q8IZF0, B1AL88
Pockets: 20 · best druggability 0.89

Structure

electron microscopy · 5 distinct chains · 57% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein unc-80 homolog	protein	1763	60% helix, 2% strand	Q8N2C7
B	Protein unc-79 homolog	protein	1663	57% helix, 1% strand	Q9P2D8
E	Calmodulin-1	protein	126	56% helix, 3% strand	P0DP23
C	Sodium leak channel non-selective PROTEIN,EXTENDED tegument protein PP150	protein	1394	58% helix, 1% strand	Q8IZF0
D	Transmembrane protein FAM155A	protein	182	34% helix, 3% strand	B1AL88

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	759	0.89	0.92	119	empty
2	572	0.88	0.93	94	empty
3	1154	0.87	0.88	103	empty
4	713	0.87	0.90	85	empty
5	815	0.83	0.85	78	empty

Interfaces

6 interfaces between chains.

A–B · 5412 Å² buried · 30 hydrogen bonds · protein-protein
C–D · 2378 Å² buried · 16 hydrogen bonds · protein-protein
A–C · 2175 Å² buried · 9 hydrogen bonds · protein-protein
E–C · 1414 Å² buried · 7 hydrogen bonds · protein-protein
A–E · 332 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

7WJI · Architecture of the human NALCN channelosome · the same entry in another collection · chain D against D, TM-score 1.00
Q8IZF0 · AlphaFold monomer V2.0 prediction for sodium leak channel non- selective protein (Q8IZF0) · a predicted model of the same protein · chain C against A, TM-score 0.94
B1AL88 · AlphaFold monomer V2.0 prediction for transmembrane protein FAM155A (B1AL88) · a predicted model of the same protein · chain D against A, TM-score 0.78
P0DP23 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP23) · a predicted model of the same protein · chain E against A, TM-score 0.46
Q9P2D8 · AlphaFold monomer V2.0 prediction for protein unc-79 homolog (Q9P2D8) · a predicted model of the same protein · chain B against A, TM-score 0.44

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8N2C7
Every structure of UniProt Q9P2D8
Every structure of UniProt P0DP23
Every structure of UniProt Q8IZF0
Every structure of UniProt B1AL88
Elsewhere: RCSB PDB 7WJI · PDBe 7WJI · UniProt Q8N2C7 · UniProt Q9P2D8 · UniProt P0DP23 · UniProt Q8IZF0 · UniProt B1AL88

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