MolNFT v1 · #190106 · protein

X-ray structure of thermostabilized drosophila dopamine transporter with GABA TRANSPORTER1-like substitutions in the binding site, in complex with NO711.

7WGT: “X-ray structure of thermostabilized drosophila dopamine transporter with GABA TRANSPORTER1-like substitutions…”. X-ray diffraction, 5 ligands (9BC, CLR, Y01). MolNFT v1 #190106 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7WGT
Type: protein
Length: 969 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q7K4Y6
Ligands: 9BC, CLR, Y01, NA, CL

Structure

x-ray diffraction · 3 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	536	—	Q7K4Y6
L	—	protein	214	—	—
H	—	protein	219	—	—

Ligands and binding sites

9BC · 1-(2-{[(diphenylmethylidene)amino]oxy}ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid · ligand · chains A
CLR · Cholesterol · ligand · chains A
Y01 · Cholesterol hemisuccinate · ligand · chains A
NA · Sodium ion · metal · 2 copies · chains A
CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7WGT · X-ray structure of thermostabilized Drosophila dopamine transporter with GABA… · the same entry in another collection · chain A against A, TM-score 1.00
Q7K4Y6 · AlphaFold monomer V2.0 prediction for sodium-dependent dopamine transporter (Q7K4Y6) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7K4Y6
Elsewhere: RCSB PDB 7WGT · PDBe 7WGT · UniProt Q7K4Y6

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