MolNFT v1 · #189918 · protein
Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 2-gq protein complex
7W57 · Guanine nucleotide-binding protein G(Q) subunit alpha: “Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 2-gq protein complex”. Electron microscopy, 14 pockets (best druggability 0.82). MolNFT v1 #189918 on…
- PDB
- 7W57
- Type
- protein
- Length
- 1,158 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(Q) subunit alpha; Guanine nucleotide-binding protein…
- UniProt
- P62873, Q5H8A3, P59768
- Pockets
- 14 · best druggability 0.82
Structure
electron microscopy · 6 distinct chains · 36% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(Q) subunit alpha | protein | 229 | 47% helix, 19% strand | — |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 336 | 7% helix, 46% strand | P62873 |
| C | Neuromedin-S | protein | 11 | 0% helix, 0% strand | Q5H8A3 |
| E | SCFV16 | protein | 232 | 6% helix, 47% strand | — |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 53 | 60% helix, 0% strand | P59768 |
| R | Neuromedin-U receptor 2 | protein | 297 | 80% helix, 3% strand | — |
Pockets
14 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 637 | 0.82 | 0.87 | 54 | empty |
| 2 | 1043 | 0.77 | 0.79 | 77 | empty |
| 3 | 879 | 0.76 | 0.79 | 67 | empty |
| 4 | 128 | 0.71 | 0.92 | 30 | empty |
| 5 | 328 | 0.63 | 0.80 | 56 | empty |
Interfaces
7 interfaces between chains.
- B–G · 2147 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 1464 Ų buried · 27 hydrogen bonds · protein-protein
- A–R · 1414 Ų buried · 12 hydrogen bonds · protein-protein
- C–R · 917 Ų buried · 22 hydrogen bonds · protein-protein
- A–E · 559 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7W57 · Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 2-Gq protein complex · the same entry in another collection · chain R against R, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.96
- Q5H8A3 · AlphaFold monomer V2.0 prediction for neuromedin-S (Q5H8A3) · a predicted model of the same protein · chain C against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62873
- Every structure of UniProt Q5H8A3
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 7W57 · PDBe 7W57 · UniProt P62873 · UniProt Q5H8A3 · UniProt P59768
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