Cryo-EM structure of C22:0-CoA bound human very long-chain fatty acid ABC transporter ABCD1

Structure

electron microscopy · 1 distinct chain.

Ligands and binding sites

• Y01 · Cholesterol hemisuccinate · ligand · 2 copies · chains A, B
• FFI · S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] docosanethioate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7VZB · Cryo-EM structure of C22:0-CoA bound human very long-chain fatty acid ABC transporter… · the same entry in another collection · chain A against A, TM-score 1.00
• P33897 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family D member 1 (P33897) · a predicted model of the same protein · chain B against A, TM-score 0.91

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O45730
• Every structure of UniProt P33897
• Elsewhere: RCSB PDB 7VZB · PDBe 7VZB · UniProt O45730 · UniProt P33897