UniProt P33897
ATP-binding cassette sub-family D member 1 (P33897)
ATP-binding cassette sub-family D member 1 (UniProt P33897), EC 3.1.2.-, 7.6.2.-: 18 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 165 pockets. Binding sites, druggability and experiment against…
- UniProt
- P33897
- Protein
- ATP-binding cassette sub-family D member 1
- EC
- 3.1.2.-, 7.6.2.-, 7.6.2.4
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 165 · 10 records with a druggable one
Structures
19 records of P33897 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7RR9 | Cryo-EM Structure of Nanodisc reconstituted ABCD1 in nucleotide bound outward open conformation | electron microscopy | A, B | UNL, CLR, MG, AGS | 20 (best 0.85) |
| 7RR9 | Cryo-EM structure of nanodisc reconstituted ABCD1 in nucleotide bound outward open conformation | electron microscopy | A, B | UNL, CLR, MG, AGS | — |
| 7RRA | Cryo-EM Structure of Nanodisc reconstituted ABCD1 in inward open conformation | electron microscopy | B, A | — | 17 (best 0.84) |
| 7RRA | Cryo-EM structure of nanodisc reconstituted ABCD1 in inward open conformation | electron microscopy | B, A | — | — |
| 7SHM | Cryo-EM structure of ATP-bound human peroxisomal fatty acid transporter ABCD1 | electron microscopy | A, B | ATP | 18 (best 0.87) |
| 7SHM | Cryo-EM structure of ATP-bound human peroxisomal fatty acid transporter ABCD1 | electron microscopy | A, B | ATP | — |
| 7SHN | Cryo-EM structure of oleoyl-CoA-bound human peroxisomal fatty acid transporter ABCD1 | electron microscopy | A, B | 3VV | — |
| 7VR1 | Cryo-EM structure of the ATP-binding cassette sub-family D member 1 from Homo sapiens | electron microscopy | B, A | — | 13 (best 0.75) |
| 7VWC | Cryo-EM structure of human very long-chain fatty acid ABC transporter ABCD1 | electron microscopy | A, B | 82T | — |
| 7VX8 | Cryo-EM structure of ATP-bound human very long-chain fatty acid ABC transporter ABCD1 | electron microscopy | B, A | ATP, MG | 14 (best 0.87) |
| 7VX8 | Cryo-EM structure of ATP-bound human very long-chain fatty acid ABC transporter ABCD1 | electron microscopy | B, A | ATP, MG | — |
| 7VZB | Cryo-EM structure of C22:0-CoA bound human very long-chain fatty acid ABC transporter ABCD1 | electron microscopy | A, B | Y01, FFI | — |
| 7X07 | Cryo-EM structure of human ABCD1 in the presence of C26:0 | electron microscopy | A, B | 7PO | 20 (best 0.80) |
| 7X0T | Cryo-EM structure of human ABCD1 E630Q in the presence of C26:0-CoA and ATP | electron microscopy | A, B | CO8, ATP | 12 (best 0.81) |
| 7X0Z | Cryo-EM structure of human ABCD1 E630Q in the presence of ATP and Magnesium in outward-facing state | electron microscopy | A, B | MG, ATP | 18 (best 0.88) |
| 7X1W | Cryo-EM structure of human ABCD1 E630Q in the presence of ATP in inward-facing state | electron microscopy | A, B | ATP | 20 (best 0.85) |
| 7XEC | Cryo-EM structure of human ABCD1 E630Q in the presence of ATP in inward-facing state 2 | electron microscopy | A, B | ATP | — |
| 7YRQ | Cryo-EM structure of human Peroxisomal ABC Transporter ABCD1 | electron microscopy | A, B | K9G | 13 (best 0.80) |
| P33897 | AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family D member 1 (P33897) | predicted | A | — | — |
Ligands
- ATP · Adenosine-5'-triphosphate · in 8 records
- MG · Magnesium ion · in 5 records
- AGS · Phosphothiophosphoric acid-adenylate ester · in 2 records
- CLR · Cholesterol · in 2 records
- UNL · Unknown ligand · in 2 records
- 3VV · S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3, 5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2, 4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) · in 1 record
- 7PO · hexacosanoic acid · in 1 record
- 82T · [(2R)-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-oxidanyl-propyl] octadecanoate · in 1 record
- CO8 · Octanoyl-coenzyme A · in 1 record
- FFI · S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] docosanethioate · in 1 record
- K9G · [(2~{R})-1-hexadecanoyloxy-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propan-2-yl] octadec-9-enoate · in 1 record
- Y01 · Cholesterol hemisuccinate · in 1 record
Experiment against prediction
- 7VX8 chain B against the predicted model P33897: TM-score 0.92, RMSD 2.87 Å
- 7VX8 chain B against the predicted model P33897: TM-score 0.92, RMSD 2.87 Å
- 7VX8 chain A against the predicted model P33897: TM-score 0.92, RMSD 2.87 Å
- 7VX8 chain A against the predicted model P33897: TM-score 0.92, RMSD 2.87 Å
- 7X0Z chain A against the predicted model P33897: TM-score 0.92, RMSD 2.85 Å
- 7X0Z chain B against the predicted model P33897: TM-score 0.91, RMSD 2.86 Å
- 7VZB chain B against the predicted model P33897: TM-score 0.91, RMSD 2.75 Å
- 7VZB chain A against the predicted model P33897: TM-score 0.91, RMSD 2.75 Å
- 7SHM chain A against the predicted model P33897: TM-score 0.90, RMSD 3.12 Å
- 7SHM chain A against the predicted model P33897: TM-score 0.90, RMSD 3.12 Å
Elsewhere
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