MolNFT v1 · #189718 · protein
Structure of human SGLT2-MAP17 complex bound with empagliflozin
7VSI: “Structure of human SGLT2-MAP17 complex bound with empagliflozin”. Electron microscopy, 2 ligands (PLM, 7R3). MolNFT v1 #189718 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7VSI
- Type
- protein
- Length
- 616 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P31639, Q13113
- Ligands
- PLM, 7R3
Structure
electron microscopy · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 586 | — | P31639 |
| B | — | protein | 30 | — | Q13113 |
Ligands and binding sites
- PLM · Palmitic acid · ligand · 2 copies · chains A
- 7R3 · (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3, 4,5-triol · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7VSI · Structure of human SGLT2-MAP17 complex bound with empagliflozin · the same entry in another collection · chain A against A, TM-score 1.00
- P31639 · AlphaFold monomer V2.0 prediction for SODIUM/GLUCOSE cotransporter 2 (P31639) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q13113 · AlphaFold monomer V2.0 prediction for PDZK1-interacting protein 1 (Q13113) · a predicted model of the same protein · chain B against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31639
- Every structure of UniProt Q13113
- Elsewhere: RCSB PDB 7VSI · PDBe 7VSI · UniProt P31639 · UniProt Q13113
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