UniProt P31639
Sodium/glucose cotransporter 2 (P31639)
Sodium/glucose cotransporter 2 (UniProt P31639): 9 experimental structures on GenesisL1, 9 ligands bound, 58 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P31639
- Protein
- Sodium/glucose cotransporter 2
- Experimental structures
- 9
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 58 · 7 records with a druggable one
Structures
9 records of P31639 in the MolNFT archive: 9 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7VSI | Structure of human SGLT2-MAP17 complex bound with empagliflozin | electron microscopy | A | PLM, 7R3 | 7 (best 0.81) |
| 7VSI | Structure of human SGLT2-MAP17 complex bound with empagliflozin | electron microscopy | A | PLM, 7R3 | — |
| 7YNJ | Structure of human SGLT2-MAP17 complex bound with substrate AMG in the occluded conformation | electron microscopy | A | GYP | 7 (best 0.79) |
| 7YNK | Structure of human SGLT2-MAP17 complex in the apo state in the inward-facing conformation | electron microscopy | A | — | 10 (best 0.82) |
| 8HB0 | Structure of human SGLT2-MAP17 complex with TA1887 | electron microscopy | A | NAG, KZ3, NA | 9 (best 0.82) |
| 8HEZ | Structure of human SGLT2-MAP17 complex with Dapagliflozin | electron microscopy | A | NAG, LE6, NA | 9 (best 0.82) |
| 8HG7 | Structure of human SGLT2-MAP17 complex with Sotagliflozin | electron microscopy | A | NAG, LFL, NA | 9 (best 0.84) |
| 8HIN | Structure of human SGLT2-MAP17 complex with Phlorizin | electron microscopy | A | NAG, LN9 | 7 (best 0.82) |
| P31639 | AlphaFold monomer V2.0 prediction for SODIUM/GLUCOSE cotransporter 2 (P31639) | — | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- NA · Sodium ion · in 3 records
- 7R3 · (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3, 4,5-triol · in 2 records
- PLM · Palmitic acid · in 2 records
- GYP · methyl alpha-D-glucopyranoside · in 1 record
- KZ3 · (2R,3R,4S,5S,6R)-2-[3-[(4-cyclopropylphenyl)methyl]-4-fluoranyl-indol-1-yl]-6-(hydroxymethyl)oxane-3,4,5-triol · in 1 record
- LE6 · (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol · in 1 record
- LFL · (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyl-oxane-3,4,5-triol · in 1 record
- LN9 · 1-[2-[(2S,3R,4S,5S,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,6-bis(oxidanyl)phenyl]-3-(4-hydroxyphenyl)propan-1-one · in 1 record
Elsewhere
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