MolNFT v1 · #189399 · protein
Crystal structure of gabarap complexed with the TEX264 lir phosphorylated at SER271 and SER272
7VEC · Gamma-aminobutyric acid receptor-associated protein: “Crystal structure of gabarap complexed with the TEX264 lir phosphorylated at SER271 and SER272”. X-ray diffraction, 15 pockets (best druggability 0.79). MolNFT v1 #189399 on…
- PDB
- 7VEC
- Type
- protein
- Length
- 1,479 residues
- Chains
- 23
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-aminobutyric acid receptor-associated protein; TEX264 phospho-lir
- UniProt
- O95166
- Pockets
- 15 · best druggability 0.79
Structure
x-ray diffraction · 6 distinct chains · 29% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, G, H, I, J, K, L | Gamma-aminobutyric acid receptor-associated protein | protein | 116 | 33% helix, 22% strand | O95166 |
| F | Gamma-aminobutyric acid receptor-associated protein | protein | 115 | 33% helix, 23% strand | O95166 |
| M, N, R, S, V | TEX264 phospho-lir | protein | 8 | 0% helix, 25% strand | — |
| O, P, Q, T | TEX264 phospho-lir | protein | 9 | 0% helix, 22% strand | — |
| U | TEX264 phospho-lir | protein | 7 | 0% helix, 29% strand | — |
| X | TEX264 phospho-lir | protein | 5 | 0% helix, 40% strand | — |
Pockets
15 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 492 | 0.79 | 0.86 | 55 | empty |
| 2 | 500 | 0.77 | 0.84 | 48 | empty |
| 3 | 666 | 0.67 | 0.76 | 72 | empty |
| 4 | 322 | 0.64 | 0.80 | 38 | empty |
| 5 | 85 | 0.47 | 0.81 | 16 | empty |
Interfaces
39 interfaces between chains.
- G–S · 743 Ų buried · 9 hydrogen bonds · protein-protein
- C–O · 734 Ų buried · 16 hydrogen bonds · protein-protein
- B–N · 732 Ų buried · 14 hydrogen bonds · protein-protein
- A–M · 730 Ų buried · 12 hydrogen bonds · protein-protein
- F–R · 730 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 21 modified (phosphorylation).
Compared structures
- 7VEC · Crystal structure of GABARAP complexed with the TEX264 LIR phosphorylated at Ser271 and… · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95166
- Elsewhere: RCSB PDB 7VEC · PDBe 7VEC · UniProt O95166
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