Research workbench
Crystal structure of gabarap complexed with the TEX264 lir phosphorylated at SER271 and SER272
Analyse Crystal structure of gabarap complexed with the TEX264 lir phosphorylated at… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7VEC
- Type
- protein
- Length
- 1,479 residues
- Chains
- 23
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-aminobutyric acid receptor-associated protein; TEX264 phospho-lir
- UniProt
- O95166
- Pockets
- 15 · best druggability 0.79
Structure
x-ray diffraction · 6 distinct chains · 29% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, G, H, I, J, K, L | Gamma-aminobutyric acid receptor-associated protein | protein | 116 | 33% helix, 22% strand | O95166 |
| F | Gamma-aminobutyric acid receptor-associated protein | protein | 115 | 33% helix, 23% strand | O95166 |
| M, N, R, S, V | TEX264 phospho-lir | protein | 8 | 0% helix, 25% strand | — |
| O, P, Q, T | TEX264 phospho-lir | protein | 9 | 0% helix, 22% strand | — |
| U | TEX264 phospho-lir | protein | 7 | 0% helix, 29% strand | — |
| X | TEX264 phospho-lir | protein | 5 | 0% helix, 40% strand | — |
Pockets
15 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 492 | 0.79 | 0.86 | 55 | empty |
| 2 | 500 | 0.77 | 0.84 | 48 | empty |
| 3 | 666 | 0.67 | 0.76 | 72 | empty |
| 4 | 322 | 0.64 | 0.80 | 38 | empty |
| 5 | 85 | 0.47 | 0.81 | 16 | empty |
Interfaces
39 interfaces between chains.
- G–S · 743 Ų buried · 9 hydrogen bonds · protein-protein
- C–O · 734 Ų buried · 16 hydrogen bonds · protein-protein
- B–N · 732 Ų buried · 14 hydrogen bonds · protein-protein
- A–M · 730 Ų buried · 12 hydrogen bonds · protein-protein
- F–R · 730 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 21 modified (phosphorylation).
Compared structures
- 7VEC · Crystal structure of GABARAP complexed with the TEX264 LIR phosphorylated at Ser271 and… · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95166
- Elsewhere: RCSB PDB 7VEC · PDBe 7VEC · UniProt O95166
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