MolNFT v1 · #189234 · protein
Thermostabilized human prestin in complex with salicylate
7V75: “Thermostabilized human prestin in complex with salicylate”. Electron microscopy, 3 ligands (LBN, CLR, SAL), 5 pockets (best druggability 0.72). MolNFT v1 #189234 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7V75
- Type
- protein
- Length
- 605 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Prestin
- Ligands
- LBN, CLR, SAL
- Pockets
- 5 · best druggability 0.72
Structure
electron microscopy · 1 distinct chain · 66% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Prestin | protein | 605 | 66% helix, 7% strand | — |
Ligands and binding sites
- LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · ligand · 8 copies · chains A
- CLR · Cholesterol · ligand · 2 copies · chains A
- SAL · 2-hydroxybenzoic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 81 | 0.72 | 0.95 | 20 | SAL |
| 2 | 291 | 0.56 | 0.76 | 42 | empty |
| 3 | 268 | 0.55 | 0.76 | 32 | empty |
| 4 | 148 | 0.46 | 0.76 | 19 | empty |
| 5 | 80 | 0.35 | 0.76 | 18 | empty |
Compared structures
- 7V75 · Thermostabilized human prestin in complex with salicylate · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7V75 · PDBe 7V75
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