MolNFT v1 · #188925 · protein
Human TMEM175 in an open state
7UNL · ENDOSOMAL/LYSOSOMAL potassium channel TMEM175: “Human TMEM175 in an open state”. Electron microscopy, 1 ligand (K), 10 pockets (best druggability 0.80). MolNFT v1 #188925 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7UNL
- Type
- protein
- Length
- 734 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ENDOSOMAL/LYSOSOMAL potassium channel TMEM175
- UniProt
- Q9BSA9
- Ligands
- K
- Pockets
- 10 · best druggability 0.80
Structure
electron microscopy · 1 distinct chain · 80% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | ENDOSOMAL/LYSOSOMAL potassium channel TMEM175 | protein | 367 | 80% helix, 2% strand | Q9BSA9 |
Ligands and binding sites
- K · Potassium ion · metal · 8 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 689 | 0.80 | 0.85 | 92 | K |
| 2 | 403 | 0.66 | 0.79 | 51 | empty |
| 3 | 309 | 0.63 | 0.79 | 37 | empty |
| 4 | 411 | 0.60 | 0.75 | 43 | empty |
| 5 | 244 | 0.53 | 0.76 | 30 | empty |
Interfaces
1 interface between chains.
- A–B · 3182 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BSA9
- Elsewhere: RCSB PDB 7UNL · PDBe 7UNL · UniProt Q9BSA9
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