UniProt Q9BSA9
Endosomal/lysosomal potassium channel TMEM175 (Q9BSA9)
Endosomal/lysosomal potassium channel TMEM175 (UniProt Q9BSA9): 16 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 73 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9BSA9
- Protein
- Endosomal/lysosomal potassium channel TMEM175
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 73 · 6 records with a druggable one
Structures
17 records of Q9BSA9 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6W8N | Structure of a trans-membrane protein | electron microscopy | A, B | — | — |
| 6W8O | Structure of an Apo membrane protein | electron microscopy | A, B | — | — |
| 6W8O | Structure of an apo membrane protein | electron microscopy | A, B | — | — |
| 6W8P | Structure of membrane protein with ions | electron microscopy | A, B | K | — |
| 6WC9 | Human open state TMEM175 in kcl | electron microscopy | A, B | K | — |
| 6WCA | Human closed state TMEM175 in kcl | electron microscopy | A, B | K | — |
| 6WCB | Human open state TMEM175 in cscl | electron microscopy | A, B | CS | — |
| 6WCC | Human closed state TMEM175 in cscl | electron microscopy | A, B | CS | — |
| 7LF6 | Structure of lysosomal membrane protein | electron microscopy | A, B | — | — |
| 7UNL | Human TMEM175 in an open state | electron microscopy | A, B | K | — |
| 7UNM | Human TMEM175 in an closed state | electron microscopy | B, A | K | 7 (best 0.75) |
| 7UNM | Human TMEM175 in an closed state | electron microscopy | B, A | K | — |
| 8DHM | Human TMEM175 in complex with 4-aminopyridine | electron microscopy | B, A | K, 4AP | 10 (best 0.80) |
| 8FY5 | Human TMEM175-LAMP1 full-length complex | electron microscopy | A, B | — | 17 (best 0.79) |
| 8FYF | Human TMEM175-LAMP1 transmembrane domain only complex | electron microscopy | A, B | — | 18 (best 0.80) |
| 8VIC | AP-6 bound human TMEM175 | electron microscopy | A, B | A1AA3 | 16 (best 0.75) |
| Q9BSA9 | AlphaFold monomer V2.0 prediction for ENDOSOMAL/LYSOSOMAL potassium channel TMEM175 (Q9BSA9) | predicted | A | — | 5 (best 0.81) |
Ligands
Experiment against prediction
- 7LF6 chain A against the predicted model Q9BSA9: TM-score 0.89, RMSD 2.76 Å
- 6W8N chain A against the predicted model Q9BSA9: TM-score 0.88, RMSD 2.76 Å
- 6W8O chain A against the predicted model Q9BSA9: TM-score 0.88, RMSD 3.02 Å
- 6W8O chain A against the predicted model Q9BSA9: TM-score 0.88, RMSD 3.02 Å
- 8VIC chain A against the predicted model Q9BSA9: TM-score 0.88, RMSD 2.74 Å
- 7UNM chain B against the predicted model Q9BSA9: TM-score 0.88, RMSD 2.76 Å
- 7UNM chain B against the predicted model Q9BSA9: TM-score 0.88, RMSD 2.76 Å
- 8VIC chain B against the predicted model Q9BSA9: TM-score 0.88, RMSD 2.75 Å
- 7UNM chain A against the predicted model Q9BSA9: TM-score 0.88, RMSD 2.76 Å
- 6WCC chain A against the predicted model Q9BSA9: TM-score 0.88, RMSD 2.80 Å
Elsewhere
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