MolNFT v1 · #188920 · protein
Complex of UBE2O with NAP1L1
7UN6 · (E3-independent) E2 ubiquitin-conjugating enzyme: “Complex of UBE2O with NAP1L1”. Electron microscopy, 10 pockets (best druggability 0.80). MolNFT v1 #188920 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7UN6
- Type
- protein
- Length
- 1,118 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- (E3-independent) E2 ubiquitin-conjugating enzyme; Nucleosome assembly protein 1-like 1
- EC
- 2.3.2.24
- UniProt
- Q9C0C9, P55209
- Pockets
- 10 · best druggability 0.80
Structure
electron microscopy · 3 distinct chains · 29% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) | protein | 648 | 20% helix, 32% strand | Q9C0C9 |
| B | Nucleosome assembly protein 1-like 1 | protein | 240 | 40% helix, 21% strand | P55209 |
| C | Nucleosome assembly protein 1-like 1 | protein | 230 | 42% helix, 17% strand | P55209 |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1134 | 0.80 | 0.81 | 106 | empty |
| 2 | 199 | 0.58 | 0.81 | 33 | empty |
| 3 | 229 | 0.55 | 0.77 | 40 | empty |
| 4 | 69 | 0.51 | 0.85 | 20 | empty |
| 5 | 146 | 0.49 | 0.79 | 30 | empty |
Interfaces
3 interfaces between chains.
- B–C · 2061 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 456 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 321 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7UN6 · Complex of UBE2O with NAP1L1 · the same entry in another collection · chain A against A, TM-score 1.00
- P55209 · AlphaFold monomer V2.0 prediction for nucleosome assembly protein 1-like 1 (P55209) · a predicted model of the same protein · chain B against A, TM-score 0.96
- Q9C0C9 · AlphaFold monomer V2.0 prediction for (E3-independent) E2 ubiquitin- conjugating enzyme… · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9C0C9
- Every structure of UniProt P55209
- Elsewhere: RCSB PDB 7UN6 · PDBe 7UN6 · UniProt Q9C0C9 · UniProt P55209
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