MolNFT v1 · #188169 · protein
Cryo-EM structure of GLUN1B-2B nmdar in complex with FAB5 in non- ACTIVE2-like conformation
7TET · Glutamate receptor ionotropic, NMDA 1: “Cryo-EM structure of GLUN1B-2B nmdar in complex with FAB5 in non- ACTIVE2-like conformation”. Electron microscopy, 20 pockets (best druggability 0.87). MolNFT v1 #188169 on GenesisL1: 3D…
- PDB
- 7TET
- Type
- protein
- Length
- 3,563 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor ionotropic, NMDA 1; Glutamate receptor ionotropic, NMDA 2B; FAB5 heavy…
- UniProt
- P35439, Q00960
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 5 distinct chains · 33% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Glutamate receptor ionotropic, NMDA 1 | protein | 786 | 35% helix, 14% strand | P35439 |
| B | Glutamate receptor ionotropic, NMDA 2B | protein | 769 | 37% helix, 14% strand | Q00960 |
| D | Glutamate receptor ionotropic, NMDA 2B | protein | 770 | 37% helix, 14% strand | Q00960 |
| H, M | FAB5 heavy chain | protein | 114 | 3% helix, 54% strand | — |
| L, N | FAB5 light chain | protein | 112 | 0% helix, 40% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1034 | 0.87 | 0.88 | 148 | empty |
| 2 | 554 | 0.85 | 0.91 | 69 | empty |
| 3 | 356 | 0.82 | 0.91 | 63 | empty |
| 4 | 542 | 0.81 | 0.87 | 68 | empty |
| 5 | 224 | 0.81 | 0.94 | 42 | empty |
Interfaces
14 interfaces between chains.
- C–D · 3425 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 3378 Ų buried · 22 hydrogen bonds · protein-protein
- B–C · 2906 Ų buried · 23 hydrogen bonds · protein-protein
- A–D · 2895 Ų buried · 24 hydrogen bonds · protein-protein
- H–L · 903 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 disulfide (disulfide).
Compared structures
- 7TET · Cryo-EM structure of GluN1b-2B NMDAR in complex with Fab5 in non-active2-like conformation · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35439
- Every structure of UniProt Q00960
- Elsewhere: RCSB PDB 7TET · PDBe 7TET · UniProt P35439 · UniProt Q00960
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