MolNFT v1 · #188167 · protein
Cryo-EM structure of GLUN1B-2B nmdar in complex with FAB5 non-ACTIVE2 conformation
7TER · Glutamate receptor ionotropic, NMDA 1: “Cryo-EM structure of GLUN1B-2B nmdar in complex with FAB5 non-ACTIVE2 conformation”. Electron microscopy, 20 pockets (best druggability 0.88). MolNFT v1 #188167 on GenesisL1: 3D structure…
- PDB
- 7TER
- Type
- protein
- Length
- 4,018 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor ionotropic, NMDA 1; Glutamate receptor ionotropic, NMDA 2B; FAB5 heavy…
- UniProt
- P35439, Q00960
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 4 distinct chains · 29% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Glutamate receptor ionotropic, NMDA 1 | protein | 795 | 35% helix, 15% strand | P35439 |
| B, D | Glutamate receptor ionotropic, NMDA 2B | protein | 784 | 36% helix, 15% strand | Q00960 |
| H, M | FAB5 heavy chain | protein | 215 | 3% helix, 45% strand | — |
| L, N | FAB5 light chain | protein | 215 | 4% helix, 42% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 603 | 0.88 | 0.93 | 103 | empty |
| 2 | 975 | 0.87 | 0.88 | 95 | empty |
| 3 | 1037 | 0.87 | 0.88 | 113 | empty |
| 4 | 966 | 0.86 | 0.87 | 108 | empty |
| 5 | 582 | 0.86 | 0.91 | 83 | empty |
Interfaces
13 interfaces between chains.
- A–B · 3028 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 3028 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 2616 Ų buried · 18 hydrogen bonds · protein-protein
- A–D · 2549 Ų buried · 19 hydrogen bonds · protein-protein
- M–N · 1965 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 7TER · Cryo-EM structure of GluN1b-2B NMDAR in complex with Fab5 non-active2 conformation · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35439
- Every structure of UniProt Q00960
- Elsewhere: RCSB PDB 7TER · PDBe 7TER · UniProt P35439 · UniProt Q00960
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