MolNFT v1 · #188160 · protein
Cryo-EM structure of GLUN1B-2B nmdar complexed to FAB2 non-ACTIVE2- like
7TEE · Glutamate receptor ionotropic, NMDA 1: “Cryo-EM structure of GLUN1B-2B nmdar complexed to FAB2 non-ACTIVE2- like”. Electron microscopy, 20 pockets (best druggability 0.87). MolNFT v1 #188160 on GenesisL1: 3D structure, binding sites…
- PDB
- 7TEE
- Type
- protein
- Length
- 3,567 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor ionotropic, NMDA 1; Glutamate receptor ionotropic, NMDA 2B; FAB2 heavy…
- UniProt
- P35439, Q00960
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 5 distinct chains · 27% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Glutamate receptor ionotropic, NMDA 1 | protein | 790 | 32% helix, 13% strand | P35439 |
| B, D | Glutamate receptor ionotropic, NMDA 2B | protein | 771 | 34% helix, 11% strand | Q00960 |
| H | FAB2 heavy chain | protein | 117 | 0% helix, 37% strand | — |
| L, N | FAB2 light chain | protein | 106 | 0% helix, 38% strand | — |
| M | FAB2 heavy chain | protein | 116 | 0% helix, 35% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1199 | 0.87 | 0.88 | 121 | empty |
| 2 | 714 | 0.86 | 0.90 | 99 | empty |
| 3 | 594 | 0.85 | 0.90 | 73 | empty |
| 4 | 424 | 0.84 | 0.92 | 62 | empty |
| 5 | 570 | 0.84 | 0.89 | 72 | empty |
Interfaces
11 interfaces between chains.
- C–D · 3221 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 3189 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 2839 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 2795 Ų buried · 9 hydrogen bonds · protein-protein
- M–N · 1268 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 disulfide (disulfide).
Compared structures
- 7TEE · Cryo-EM structure of GluN1b-2B NMDAR complexed to Fab2 Non-active2-like · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35439
- Every structure of UniProt Q00960
- Elsewhere: RCSB PDB 7TEE · PDBe 7TEE · UniProt P35439 · UniProt Q00960
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