MolNFT v1 · #188157 · protein
Cryo-EM structure of GLUN1B-2B nmdar complexed to FAB2 non-ACTIVE1- like
7TEB · Glutamate receptor ionotropic, NMDA 1: “Cryo-EM structure of GLUN1B-2B nmdar complexed to FAB2 non-ACTIVE1- like”. Electron microscopy, 20 pockets (best druggability 0.87). MolNFT v1 #188157 on GenesisL1: 3D structure, binding sites…
- PDB
- 7TEB
- Type
- protein
- Length
- 3,580 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor ionotropic, NMDA 1; Glutamate receptor ionotropic, NMDA 2B; FAB2 heavy…
- UniProt
- P35439, Q00960
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 6 distinct chains · 30% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor ionotropic, NMDA 1 | protein | 783 | 35% helix, 12% strand | P35439 |
| B, D | Glutamate receptor ionotropic, NMDA 2B | protein | 784 | 31% helix, 9% strand | Q00960 |
| C | Glutamate receptor ionotropic, NMDA 1 | protein | 784 | 35% helix, 11% strand | P35439 |
| H | FAB2 heavy chain | protein | 117 | 0% helix, 37% strand | — |
| L, N | FAB2 light chain | protein | 106 | 0% helix, 34% strand | — |
| M | FAB2 heavy chain | protein | 116 | 0% helix, 35% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1083 | 0.87 | 0.88 | 106 | empty |
| 2 | 176 | 0.82 | 0.97 | 41 | empty |
| 3 | 239 | 0.82 | 0.94 | 49 | empty |
| 4 | 230 | 0.81 | 0.93 | 52 | empty |
| 5 | 1056 | 0.81 | 0.82 | 85 | empty |
Interfaces
11 interfaces between chains.
- A–B · 3695 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 3676 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 3006 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 2991 Ų buried · 11 hydrogen bonds · protein-protein
- M–N · 1188 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 19 disulfide (disulfide).
Compared structures
- 7TEB · Cryo-EM structure of GluN1b-2B NMDAR complexed to Fab2 non-active1-like · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35439
- Every structure of UniProt Q00960
- Elsewhere: RCSB PDB 7TEB · PDBe 7TEB · UniProt P35439 · UniProt Q00960
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