MolNFT v1 · #188115 · protein
Structure of xenopus KCNQ1-cam
7TCP · Potassium voltage-gated channel subfamily kqt member 1: “Structure of xenopus KCNQ1-cam”. Electron microscopy, 1 ligand (CA), 20 pockets (best druggability 0.83). MolNFT v1 #188115 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7TCP
- Type
- protein
- Length
- 1,912 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium voltage-gated channel subfamily kqt member 1; Calmodulin-1
- UniProt
- P70057, P0DP23
- Ligands
- CA
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 2 distinct chains · 73% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E, G, C | Potassium voltage-gated channel subfamily kqt member 1 | protein | 341 | 78% helix, 1% strand | P70057 |
| B, F, H, D | Calmodulin-1 | protein | 137 | 61% helix, 7% strand | P0DP23 |
Ligands and binding sites
- CA · Calcium ion · metal · 12 copies · chains B, F, H, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 379 | 0.83 | 0.92 | 51 | empty |
| 2 | 1000 | 0.83 | 0.84 | 88 | empty |
| 3 | 1063 | 0.73 | 0.76 | 68 | empty |
| 4 | 1080 | 0.72 | 0.76 | 69 | empty |
| 5 | 507 | 0.69 | 0.80 | 50 | empty |
Interfaces
18 interfaces between chains.
- A–G · 2704 Ų buried · 15 hydrogen bonds · protein-protein
- E–G · 2701 Ų buried · 15 hydrogen bonds · protein-protein
- E–C · 2699 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 2695 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 2483 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7TCP · Structure of Xenopus KCNQ1-CaM · the same entry in another collection · chain D against D, TM-score 1.00
- P70057 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily kqt… · a predicted model of the same protein · chain A against A, TM-score 0.96
- P0DP23 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP23) · a predicted model of the same protein · chain F against A, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P70057
- Every structure of UniProt P0DP23
- Elsewhere: RCSB PDB 7TCP · PDBe 7TCP · UniProt P70057 · UniProt P0DP23
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