Crystal structure of a superbinder fes SH2 domain (SFES1) in complex with a high affinity phosphopeptide

Structure

x-ray diffraction · 2 distinct chains · 19% helix, 25% strand (DSSP).

Ligands and binding sites

• NA · Sodium ion · metal · chains A
• CL · Chloride ion · ion · 2 copies · chains A
• EDO · 1,2-ethanediol · additive · 2 copies · chains A, B
• MLI · Malonate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 509 Ų buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

• 7T1K · Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity… · the same entry in another collection · chain A against A, TM-score 1.00
• P07332 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase FES/FPS (P07332) · a predicted model of the same protein · chain A against A, TM-score 0.97
• P15311 · AlphaFold monomer V2.0 prediction for ezrin (P15311) · a predicted model of the same protein · chain B against A, TM-score 0.68

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P07332
• Every structure of UniProt P15311
• Elsewhere: RCSB PDB 7T1K · PDBe 7T1K · UniProt P07332 · UniProt P15311