UniProt P07332
Tyrosine-protein kinase Fes/Fps (P07332)
Tyrosine-protein kinase Fes/Fps (UniProt P07332), EC 2.7.10.2: 22 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P07332
- Protein
- Tyrosine-protein kinase Fes/Fps
- EC
- 2.7.10.2
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 8 · 2 records with a druggable one
Structures
23 records of P07332 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WQU | Solution structure of the human FES SH2 domain | solution nmr | A | — | — |
| 1WQU | Solution structure of the human fes SH2 domain | solution nmr | A | — | — |
| 2DCR | Fully automated solution structure determination of the Fes SH2 domain | solution nmr | A | — | — |
| 2DCR | Fully automated solution structure determination of the fes SH2 domain | solution nmr | A | — | — |
| 3BKB | Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES) | x-ray diffraction | A | — | — |
| 3BKB | Crystal structure of human feline sarcoma viral oncogene homologue (V- fes) | x-ray diffraction | A | — | — |
| 3CBL | Crystal structure of human feline sarcoma viral oncogene homologue (v-FES) in complex with… | x-ray diffraction | A | — | — |
| 3CBL | Crystal structure of human feline sarcoma viral oncogene homologue (V- fes) in complex with… | x-ray diffraction | A | — | — |
| 3CD3 | Crystal structure of phosphorylated human feline sarcoma viral oncogene homologue (v-FES) in… | x-ray diffraction | A | — | — |
| 3CD3 | Crystal structure of phosphorylated human feline sarcoma viral oncogene homologue (V-fes) in… | x-ray diffraction | A | — | — |
| 4DYL | F-BAR domain of human FES tyrosine kinase | x-ray diffraction | A | — | — |
| 4DYL | F-bar domain of human fes tyrosine kinase | x-ray diffraction | A | — | — |
| 4E93 | Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES)in complex with TAE684 | x-ray diffraction | A | — | — |
| 4E93 | Crystal structure of human feline sarcoma viral oncogene homologue (V- FES)IN complex with TAE684 | x-ray diffraction | A | — | — |
| 6JMF | Crystal structure of human tyrosine-protein kinase Fes/Fps in complex with compound 4 | x-ray diffraction | A | SO4, 9FC | 3 (best 0.66) |
| 6JMF | Crystal structure of human tyrosine-protein kinase FES/FPS in complex with compound 4 | x-ray diffraction | A | SO4, 9FC | — |
| 7T1K | Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity… | x-ray diffraction | A | CL, NA | — |
| 7T1K | Crystal structure of a superbinder fes SH2 domain (SFES1) in complex with a high affinity… | x-ray diffraction | A | CL, NA | — |
| 7T1L | Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity… | x-ray diffraction | A, B | NA, CL | 2 (best 0.36) |
| 7T1L | Crystal structure of a superbinder fes SH2 domain (sfess) in complex with a high affinity… | x-ray diffraction | A, B | NA, CL | — |
| 8X2T | The Crystal Structure of FES from Biortus. | x-ray diffraction | A | — | — |
| 8XKP | Crystal structure of human tyrosine-protein kinase Fes/Fps in complex with compound 17c | x-ray diffraction | A | SO4, A1LWS | 3 (best 0.69) |
| P07332 | AlphaFold monomer V2.0 prediction for tyrosine-protein kinase FES/FPS (P07332) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 4 records
- NA · Sodium ion · in 4 records
- SO4 · Sulfate ion · in 3 records
- 9FC · 6-{[(1R,2S)-2-aminocyclohexyl]amino}-5-cyano-2-[(3-methylphenyl)amino]pyridine-3-carboxamide · in 2 records
- A1LWS · 7-[[(1R,2S)-2-azanylcyclohexyl]amino]-5-[[3-[(2S,6R)-2,6-dimethylmorpholin-4-yl]phenyl]amino]-4-oxidanylidene-3H-pyrido[3,4-d]pyridazine-8-carbonitrile · in 1 record
Experiment against prediction
- 3BKB chain A against the predicted model P07332: TM-score 1.00, RMSD 0.38 Å
- 3BKB chain A against the predicted model P07332: TM-score 1.00, RMSD 0.38 Å
- 6JMF chain A against the predicted model P07332: TM-score 1.00, RMSD 0.40 Å
- 6JMF chain A against the predicted model P07332: TM-score 1.00, RMSD 0.40 Å
- 8XKP chain A against the predicted model P07332: TM-score 1.00, RMSD 0.41 Å
- 3CD3 chain A against the predicted model P07332: TM-score 0.98, RMSD 0.93 Å
- 3CD3 chain A against the predicted model P07332: TM-score 0.98, RMSD 0.93 Å
- 3CBL chain A against the predicted model P07332: TM-score 0.98, RMSD 0.94 Å
- 3CBL chain A against the predicted model P07332: TM-score 0.98, RMSD 0.94 Å
- 4E93 chain A against the predicted model P07332: TM-score 0.97, RMSD 1.26 Å
Elsewhere
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