MolNFT v1 · #58995 · protein
Crystal structure of human feline sarcoma viral oncogene homologue (V- fes)
3BKB · Proto-oncogene tyrosine-protein kinase FES/FPS: “Crystal structure of human feline sarcoma viral oncogene homologue (V- fes)”. X-ray diffraction, 2 ligands (STU, SO4), 3 pockets (best druggability 0.70). MolNFT v1 #58995 on…
- PDB
- 3BKB
- Type
- protein
- Length
- 373 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proto-oncogene tyrosine-protein kinase FES/FPS
- EC
- 2.7.10.2
- UniProt
- P07332
- Ligands
- STU, SO4
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Proto-oncogene tyrosine-protein kinase FES/FPS (EC 2.7.10.2) | protein | 373 | 35% helix, 22% strand | P07332 |
Ligands and binding sites
- STU · Staurosporine · ligand · chains A
- SO4 · Sulfate ion · ion · 3 copies · chains A
- EDO · 1,2-ethanediol · additive · 8 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 424 | 0.70 | 0.81 | 53 | EDO, STU |
| 2 | 110 | 0.59 | 0.85 | 16 | EDO |
| 3 | 147 | 0.45 | 0.76 | 23 | SO4 |
Compared structures
- 3BKB · Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES) · the same entry in another collection · chain A against A, TM-score 1.00
- P07332 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase FES/FPS (P07332) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07332
- Elsewhere: RCSB PDB 3BKB · PDBe 3BKB · UniProt P07332
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