MolNFT v1 · #187859 · protein
Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha. "tips-juxtaposed" conformation
7SZ7 · Epidermal growth factor receptor: “Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha. "tips-juxtaposed"…”. Electron microscopy, 10 pockets (best druggability 0.80). MolNFT v1 #187859 on…
- PDB
- 7SZ7
- Type
- protein
- Length
- 1,328 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Epidermal growth factor receptor; Transforming growth factor alpha
- EC
- 2.7.10.1
- UniProt
- P00533, P01135
- Pockets
- 10 · best druggability 0.80
Structure
electron microscopy · 2 distinct chains · 9% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Epidermal growth factor receptor (EC 2.7.10.1) | protein | 614 | 10% helix, 21% strand | P00533 |
| C, D | Transforming growth factor alpha | protein | 50 | 0% helix, 20% strand | P01135 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 931 | 0.80 | 0.82 | 79 | empty |
| 2 | 1174 | 0.76 | 0.79 | 97 | empty |
| 3 | 498 | 0.73 | 0.82 | 60 | empty |
| 4 | 427 | 0.60 | 0.76 | 38 | empty |
| 5 | 230 | 0.59 | 0.80 | 33 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1627 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 1604 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 1524 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 56 disulfide (disulfide).
Compared structures
- 7SZ7 · Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha.… · the same entry in another collection · chain A against A, TM-score 1.00
- P01135 · AlphaFold monomer V2.0 prediction for protransforming growth factor alpha (P01135) · a predicted model of the same protein · chain C against A, TM-score 0.84
- P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain B against A, TM-score 0.53
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00533
- Every structure of UniProt P01135
- Elsewhere: RCSB PDB 7SZ7 · PDBe 7SZ7 · UniProt P00533 · UniProt P01135
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