UniProt P01135
Protransforming growth factor alpha (P01135)
Protransforming growth factor alpha (UniProt P01135): 24 experimental structures on GenesisL1, 1 ligand bound, 6 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P01135
- Protein
- Protransforming growth factor alpha
- Experimental structures
- 24
- Predicted models
- 0
- Ligands
- 1
- Pockets
- 6 · 2 records with a druggable one
Structures
24 records of P01135 in the MolNFT archive: 24 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GK5 | Solution Structure the mEGF/TGFalpha44-50 chimeric growth factor | solution nmr | A | — | — |
| 1GK5 | Solution structure the MEGF/TGFALPHA44-50 chimeric growth factor | solution nmr | A | — | — |
| 1MOX | Crystal Structure of Human Epidermal Growth Factor Receptor (residues 1-501) in complex with… | x-ray diffraction | C, D | — | — |
| 1MOX | Crystal structure of human epidermal growth factor receptor (residues 1-501) in complex with… | x-ray diffraction | C, D | — | — |
| 1P9J | Solution structure and dynamics of the EGF/TGF-alpha chimera T1E | solution nmr | A | — | — |
| 1P9J | Solution structure and dynamics of the EGF/TGF-alpha chimera T1E | solution nmr | A | — | — |
| 1YUF | Type alpha transforming growth factor, NMR, 16 models without energy minimization | solution nmr | A | — | — |
| 1YUF | Type alpha transforming growth factor, NMR, 16 models without energy minimization | solution nmr | A | — | — |
| 1YUG | Type alpha transforming growth factor, NMR, 15 models after ECEPP/3 energy minimization | solution nmr | A | — | — |
| 1YUG | Type alpha transforming growth factor, NMR, 15 models after ECEPP/3 energy minimization | solution nmr | A | — | — |
| 2TGF | The solution structure of human transforming growth factor alpha | solution nmr | A | — | — |
| 2TGF | The solution structure of human transforming growth factor alpha | solution nmr | A | — | — |
| 3E50 | Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha | x-ray diffraction | C, D | — | — |
| 3E50 | Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha | x-ray diffraction | C, D | — | — |
| 3TGF | The solution structure of human transforming growth factor alpha | solution nmr | A | — | — |
| 3TGF | The solution structure of human transforming growth factor alpha | solution nmr | A | — | — |
| 4TGF | Solution structures of human transforming growth factor alpha derived from 1*H NMR data | solution nmr | A | — | — |
| 4TGF | Solution structures of human transforming growth factor alpha derived from 1*H NMR data | solution nmr | A | — | — |
| 5KN5 | TGFalpha/Epiregulin complex with neutralizing antibody LY3016859 | x-ray diffraction | C, F | ZN | 3 (best 0.64) |
| 5KN5 | TGFALPHA/EPIREGULIN complex with neutralizing antibody LY3016859 | x-ray diffraction | C, F | ZN | — |
| 7SZ5 | Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha… | electron microscopy | C, D | — | — |
| 7SZ7 | Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha.… | electron microscopy | C, D | — | 3 (best 0.76) |
| 7SZ7 | Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha.… | electron microscopy | C, D | — | — |
| P01135 | AlphaFold monomer V2.0 prediction for protransforming growth factor alpha (P01135) | — | — | — |
Ligands
- ZN · Zinc ion · in 2 records
Experiment against prediction
- 1GK5 chain A against the predicted model P01132: TM-score 0.61, RMSD 2.22 Å
- 1GK5 chain A against the predicted model P01132: TM-score 0.61, RMSD 2.22 Å
- 1P9J chain A against the predicted model P01133: TM-score 0.50, RMSD 2.88 Å
- 1P9J chain A against the predicted model P01133: TM-score 0.50, RMSD 2.88 Å
Elsewhere
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