MolNFT v1 · #187801 · protein
Human nalcn-FAM155A-UNC79-UNC80 channelosome with cam bound, conformation 2/2
7SX4: “Human nalcn-FAM155A-UNC79-UNC80 channelosome with cam bound, conformation 2/2”. Electron microscopy, 4 ligands (Y01, PEV, PGV). MolNFT v1 #187801 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7SX4
- Type
- protein
- Length
- 4,641 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q8IZF0, A0A7G8ZY66, B1AL88, P0DP23, Q9P2D8, Q8N2C7
- Ligands
- Y01, PEV, PGV, NAG
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1383 | — | Q8IZF0, A0A7G8ZY66 |
| B | — | protein | 151 | — | B1AL88 |
| C | — | protein | 114 | — | P0DP23 |
| D | — | protein | 1406 | — | Q9P2D8 |
| E | — | protein | 1587 | — | Q8N2C7 |
Ligands and binding sites
- Y01 · Cholesterol hemisuccinate · ligand · 3 copies · chains A
- PEV · (1S)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · ligand · chains A
- PGV · (1R)-2-{[{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl (11E)-octadec-11-enoate · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7SX4 · Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 2/2 · the same entry in another collection · chain E against E, TM-score 1.00
- Q8IZF0 · AlphaFold monomer V2.0 prediction for sodium leak channel non- selective protein (Q8IZF0) · a predicted model of the same protein · chain A against A, TM-score 0.94
- B1AL88 · AlphaFold monomer V2.0 prediction for transmembrane protein FAM155A (B1AL88) · a predicted model of the same protein · chain B against A, TM-score 0.87
- P0DP23 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP23) · a predicted model of the same protein · chain C against A, TM-score 0.47
- Q9P2D8 · AlphaFold monomer V2.0 prediction for protein unc-79 homolog (Q9P2D8) · a predicted model of the same protein · chain D against A, TM-score 0.40
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IZF0
- Every structure of UniProt A0A7G8ZY66
- Every structure of UniProt B1AL88
- Every structure of UniProt P0DP23
- Every structure of UniProt Q9P2D8
- Every structure of UniProt Q8N2C7
- Elsewhere: RCSB PDB 7SX4 · PDBe 7SX4 · UniProt Q8IZF0 · UniProt A0A7G8ZY66 · UniProt B1AL88 · UniProt P0DP23 · UniProt Q9P2D8 · UniProt Q8N2C7
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